Table 5.

Spearman correlation analysis of 16α-OHE1 measured by ELISA with all estrogens and estrogen metabolites measured by LC-MS/MS

Estrogen metabolite measure (pmol)Spearman correlation coefficient
Premenopausal luteal phase womenPostmenopausal women
Parent estrogens
    E10.670.43
    E20.600.28
2-pathway*0.580.33
    2-Hydoxyestrone0.590.28
    2-Hydroxyestradiol0.480.23
    2-Methoxyestrone0.500.37
    2-Methoxyestradiol0.510.41
    2-Hydroxyestrone-3-methyl ether0.390.36
4-pathway*0.510.27
    4-OHE10.510.22
    4-Methoxyestrone0.330.29
    4-Methoxyestradiol0.380.29
16-Pathway*0.750.55
    16α-OHE10.860.62
    E30.680.43
    17-Epiestriol0.630.42
    16-Ketoestradiol0.700.58
    16-Epiestriol0.720.59
  • *2-Pathway, 4-pathway, and 16-pathway are the sum in picomoles of all estrogen metabolites listed under each pathway.