Table 4.

Spearman correlation analysis of 2-OHE1 measured by ELISA with 15 estrogen and estrogen metabolites measured by LC-MS/MS

Estrogen metabolite measure (pmol)Spearman correlation coefficient
Premenopausal luteal phase womenPostmenopausal women
Parent estrogens
    E10.560.28
    E20.480.11
2-Pathway*0.840.48
    2-Hydoxyestrone0.810.37
    2-Hydroxyestradiol0.810.59
    2-Methoxyestrone0.730.33
    2-Methoxyestradiol0.700.31
    2-Hydroxyestrone-3-methyl ether0.560.32
4-Pathway*0.700.35
    4-OHE10.700.33
    4-Methoxyestrone0.330.26
    4-Methoxyestradiol0.500.19
16-pathway*0.520.33
    16α-OHE10.540.37
    E30.480.21
    17-Epiestriol0.440.42
    16-Ketoestradiol0.470.38
    16-Epiestriol0.540.40
  • *2-Pathway, 4-pathway, and 16-pathway are the sum in picomoles of all estrogen metabolites listed under each pathway.