Table 3.

Association of NAT2 acetylation phenotype in children according to maternal dipyrone exposure during pregnancy, Brazil (Cont'd)

No dipyrone exposureAll children
IL, nControls, nCrude OR (95% CI)Adj OR* (95% CI)IL, nControls, nCrude OR (95% CI)Adj OR* (95% CI)
14162641
2874.57 (1.35–16.0)5.16 (1.63–16.4)62204.89 (2.29–10.5)5.14 (2.42–10.9)
163194
1212.25 (0.15–127.8)2.40 (0.21–27.7)1631.12 (0.16–8.80)1.20 (0.22–6.54)
30194845
4083.17 (1.12–9.19)4.27 (1.75–10.5)78233.18 (1.64–6.19)3.99 (2.19–7.28)

NOTE: **Breslow-Day and Tarone's tests of homogeneity of ORs (0–12 versus 13–21 mo strata) of women reporting dipyrone intake during the index pregnancy. χ2 = 2.096, 1 df, P = 0.148; Breslow-Day and Tarone's tests of homogeneity of ORs, 0–12 mo strata, according to dipyrone (yes versus no) intake during the index pregnancy, χ2 = 0.06, 1 df, P = 0.82; Breslow-Day and Tarone's tests of homogeneity of ORs, 13–21 mo strata, according to dipyrone intake during the index pregnancy, χ2 = 0.42, 1 df, P = 0.52; Breslow-Day and Tarone's tests of homogeneity of ORs, all ages (0–21 mo) strata, according to dipyrone intake during the index pregnancy, χ2 = 0.04, 1 df, P = 0.84.

All ages IL versus NAT2 phenotype, Mantel-Haenszel test weighted OR (dipyrone intake during pregnancy), 3.77 (95% CI, 1.90–7.64).

  • * ORs adjusted by pesticide exposure and hormonal intake during pregnancy.