Table 2.

Distribution of NAT2 diplotypes between IL cases and controls, Brazil

Diplotype NAT2IL n (%)Controls n (%)OR (95% CI)
Rapid
Rapid acetylation genotype corresponds to the presence of at least one copy of alleles of rapid acetylation capacity.4/4*2 (4.8)9 (10.4)1.00*
4/124 (9.7)8 (9.3)2.25 (0.23-30.3)
4/1301 (1.2)
11/1101 (1.2)
11/131 (2.4)3 (3.4)
12/121 (2.4)4 (4.6)1.13 (0.02-28.0)
4/58 (19.5)15 (17.4)2.40 (0.35-27.5)
4/66 (14.6)5 (5.8)2.25 (0.41-12.5)
4/706 (6.9)
11/51 (2.4)1 (1.2)
11/603 (3.4)
11/701 (1.2)
12/57 (17.1)11 (12.7)2.86 (0.39-33.8)
12/64 (9.7)16 (18.6)1.13 (0.13-14.7)
12/72 (4.8)9 (10.4)1.00 (0.06-16.7)
12/143 (7.3)3 (3.4)4.50 (0.31-73.2)
13/52 (4.8)2 (2.3)4.50 (0.19-94.7)
12/1303 (3.4)
    Total Rapid43 (100)86 (100)2.40 (0.46-23.7)
Slow
Slow-acetylation genotype corresponds to the presence of two alleles withslow acetylation capacity.5/57 (7.8)5 (11.1)6.30 (0.72-78.3)
6/65 (5.6)4 (8.8)5.63 (0.54-76.4)
7/73 (3.4)0
5/639 (43.8)15 (33.3)11.7 (2.00-118.4)
5/717 (19.1)11 (24.4)6.95 (1.08-74.2)
5/149 (10.1)3 (6.6)13.5 (1.37-174.2)
6/75 (5.6)2 (4.4)11.2 (0.83-180.1)
6/144 (4.4)1 (2.2)
7/141 (1.1)2 (4.4))
    Total Slow89 (100)45 (100)8.90 (1.71-86.7)
Total132 (100)131 (100)

NOTE: n, number of individuals.

  • *Used as reference.