Table 1.

Demographic and laboratory characteristics and NAT2 allele frequency of IL cases and controls, Brazil, 2000-2008

IL n (%)Controls n (%)OR (95% CI)
Mean age (mo)
    0-1247 (35.6)48 (36.6)
    13-2165 (49.2)83 (63.3)
Gender
    Male83 (62.8)71 (54.1)
    Female49 (37.1)60 (45.8)
Race distribution
    White70 (53.0)72 (54.9)
    Non-white62 (46.9)59 (45.0)
Maternal dipyrone exposure
    Yes57 (43.1)45 (34.3)1.78 (0.98-3.23)
    No42 (32.1)59 (45.0)1.0*
    Unknown33 (25.0)37 (28.2)
MLL rearrangements
    Rearranged45 (34.0)
    Wild-type42 (31.8)
    Unknown25 (18.9)
Frequency of NAT2 haplotypes
    Rapid
        *420 (15.1)41 (31.2)1.00*
        *11A4 (3.0)18 (13.7)0.46 (0.10-1.66)
        *1220 (15.1)56 (42.7)0.73 (0.33-1.64)
        *13A3 (2.2)9 (6.8)0.68 (0.11-3.16)
    Slow
        *1413 (9.8)11 (8.3)2.42 (0.83-7.12)
        *573 (55.3)62 (47.3)2.41 (1.23-4.78)
        *651 (38.6)45 (34.3)2.32 (1.13-4.80)
        *724 (18.1)23 (17.5)2.14 (0.91-5.06)

NOTE: n, number of individuals; n = 132 IL cases and 131 controls.

  • *Used as reference.