Table 5.

Logistic regression analysis with HbA1c quartile as exposure in 2-year intervals (study 2: distal adenoma)a

HbA1c quartileAdjusted ORb (95% CI)
Prior year 1–2Prior year 3–4Prior year 5–6Prior year 7–8Prior year 9–10
Any adenomaAdvanced adenomaAny adenomaAdvanced adenomaAny adenomaAdvanced adenomaAny adenomaAdvanced adenomaAny adenomaAdvanced adenoma
4.46–7.00Referencen = 248Referencen = 94Referencen = 224Referencen = 67Referencen = 156Referencen = 46Referencen = 86Referencen = 24Referencen = 35Referencen = 11
7.01–7.871.0 (0.8–1.3)n = 2380.6 (0.4–0.9)cn = 591.0 (0.8–1.2)n = 1991.1 (0.7–1.6)n = 621.1 (0.8–1.4)n = 1411.4 (0.9–2.1)n = 511.0 (0.7–1.4)n = 691.1 (0.6–2.0)n = 220.9 (0.5–1.6)n = 270.4 (0.1–1.3)n = 4
7.88–9.101.0 (0.8–1.3)n = 2250.7 (0.5–1.1)n = 630.9 (0.7–1.1)n = 2111.1 (0.7–1.6)n = 661.3 (1.0–1.7)cn = 2121.3 (0.8–2.1)n = 601.1 (0.7–1.5)n = 901.1 (0.6–2.1)n = 280.8 (0.5–1.3)n = 381.1 (0.5–2.5)n = 17
9.10–17.51.1 (0.9–1.4)n = 1850.9 (0.6–1.4)n = 551.0 (0.8–1.3)n = 2111.1 (0.7–1.7)n = 581.0 (0.8–1.4)n = 1751.1 (0.7–1.8)n = 521.1 (0.8–1.6)n = 1141.3 (0.7–2.3)n = 320.9 (0.6–1.6)n = 401.1 (0.5–2.7)n = 15
Missing1.5 (1.1–2.1)cn = 551.3 (0.7–2.2)n = 181.0 (0.7–1.3)n = 1061.2 (0.8–1.9)n = 361.2 (0.9–1.5)n = 2671.2 (0.8–1.9)n = 800.9 (0.7–1.3)n = 5921.5 (0.9–2.6)n = 1831.1 (0.7–1.8)n = 8110.9 (0.4–1.9)n = 242
  • aPatients without any adenoma as controls.

  • bAdjusted for sex, age, ethnicity, BMI, income status, year of large bowel endoscopy, duration of diabetes, NSAID use, aspirin use, statin use, and acid-suppressive medication use.

  • cP < 0.05.