Table 5.

OR and 95% CI for association of serum selenium concentration (per 10 μg/L) and prostate cancer in strata of genetic polymorphisms in the EPIC-Heidelberg nested case-control study (n = 740)

Total prostate cancerHigh-grade prostate cancer
Cases/controlsOR* (95% CI)Cases/controlsOR* (95% CI)
SEP15 G1125A (rs5859)GG162/3070.91 (0.81, 1.02)63/1130.86 (0.72, 1.03)
GA + AA82/1830.96 (0.80, 1.14)27/670.95 (0.70, 1.30)
    Pinteraction0.270.32
SEP15 C>T (rs540049)CC162/3230.90 (0.80, 1.01)63/1170.85 (0.71, 1.02)
CT + TT82/1670.98 (0.82, 1.16)27/630.99 (0.73, 1.35)
    Pinteraction0.180.18
SEPP1 G>A coding (rs3877899)GG150/2700.92 (0.81, 1.05)50/1060.87 (0.69, 1.10)
GA + AA94/2200.93 (0.79, 1.08)40/740.91 (0.74, 1.13)
    Pinteraction0.820.90
SEPP1 G>A 3′UTR (rs7579)GG115/2500.92 (0.80, 1.07)41/880.89 (0.70, 1.13)
GA + AA129/2400.92 (0.80, 1.06)49/920.88 (0.70, 1.11)
    Pinteraction0.900.82
GPX1 C>T (rs1050450)CC120/2631.03 (0.89, 1.18)52/921.11 (0.90, 1.37)
CT+TT123/2220.87 (0.76, 0.99)38/850.64 (0.49, 0.83)
    Pinteraction0.03<0.001
GPX4 C718T (rs713041)CC76/1550.88 (0.73, 1.06)33/510.82 (0.63. 1.07)
CT + TT166/3330.95 (0.84, 1.06)57/1270.96 (0.79, 1.17)
    Pinteraction0.760.17

NOTE: Pinteraction, P value of test for interaction between serum selenium concentration and genotype.

  • *Unconditional logistic regression adjusted for matching factors (age and time of blood collection) and family history of prostate cancer, participation in PSA testing, smoking status, and vigorous physical activity.