Mean and 95% confidence interval of serum selenium and SePP concentration and GPx3 activity over genotypes of SNPs in selected selenoproteins in healthy participants of the EPIC-Heidelberg nested case-control study
| N | Serum Se concentration (μg/L)* | P† | N | Serum SePP concentration (mg/L)* | P† | N | Serum GPx3 activity (units/L)* | P† | |
|---|---|---|---|---|---|---|---|---|---|
| SEP15 G1125A (rs5859) | |||||||||
| GG | 307 | 87.9 (86.4, 89.4) | 308 | 2.91 (2.85, 2.96) | 309 | 656.5 (644.4, 668.7) | |||
| GA | 157 | 87.7 (85.6, 89.8) | 157 | 2.96 (2.88, 3.04) | 157 | 665.2 (648.1, 682.2) | |||
| AA | 26 | 84.0 (78.9, 89.2) | 0.36 | 26 | 2.83 (2.64, 3.03) | 0.36 | 26 | 607.7 (565.8, 649.7) | 0.05 |
| SEP15 C>T (rs540049) | |||||||||
| CC | 323 | 88.0 (86.5, 89.5) | 324 | 2.91 (2.85, 2.96) | 325 | 655.9 (644.1, 667.8) | |||
| CT | 142 | 87.5 (85.3, 89.7) | 142 | 2.97 (2.88, 3.05) | 142 | 666.9 (649.0, 684.9) | |||
| TT | 25 | 84.2 (78.9, 89.4) | 0.38 | 25 | 2.83 (2.63, 3.04) | 0.33 | 25 | 609.2 (566.4, 652.0) | 0.05 |
| SEPP1 G>A coding (rs3877899) | |||||||||
| GG | 270 | 88.1 (86.5, 89.7) | 271 | 2.95 (2.89, 3.01) | 271 | 659.2 (646.1, 672.2) | |||
| GA | 193 | 87.5 (85.7, 89.4) | 193 | 2.90 (2.82, 2.97) | 194 | 652.5 (637.0, 667.9) | |||
| AA | 27 | 83.6 (78.6, 88.7) | 0.25 | 27 | 2.83 (2.64, 3.03) | 0.40 | 27 | 662.8 (621.4, 704.3) | 0.77 |
| SEPP1 G>A 3′UTR (rs7579) | |||||||||
| GG | 250 | 87.1 (85.4, 88.7) | 250 | 2.87 (2.81, 2.94) | 250 | 651.8 (638.2, 665.4) | |||
| GA | 207 | 88.7 (86.8, 90.5) | 208 | 2.98 (2.91, 3.05) | 209 | 664.3 (649.4, 679.2) | |||
| AA | 33 | 85.8 (81.2, 90.4) | 0.31 | 33 | 2.89 (2.71, 3.06) | 0.07 | 33 | 645.9 (608.6, 683.3) | 0.40 |
| GPX1 C>T (rs1050450) | |||||||||
| CC | 263 | 87.9 (86.2, 89.5) | 264 | 2.95 (2.88, 3.01) | 264 | 655.1 (641.8, 668.4) | |||
| CT | 180 | 87.7 (85.7, 89.6) | 180 | 2.91 (2.84, 2.99) | 181 | 661.0 (644.9, 677.0) | |||
| TT | 42 | 86.8 (82.7, 90.9) | 0.89 | 42 | 2.82 (2.67, 2.98) | 0.33 | 42 | 643.5 (610.1, 676.9) | 0.63 |
| GPX4 C718T (rs713041) | |||||||||
| CC | 155 | 87.8 (85.7, 89.9) | 155 | 2.97 (2.89, 3.05) | 156 | 663.8 (646.6, 681.1) | |||
| CT | 228 | 87.1 (85.4, 88.8) | 229 | 2.86 (2.80, 2.93) | 229 | 651.2 (637.0, 665.5) | |||
| TT | 105 | 88.3 (85.8, 90.9) | 0.71 | 105 | 2.97 (2.87, 3.06) | 0.07 | 105 | 658.4 (637.4, 679.4) | 0.54 |