Table 4.

Mean and 95% confidence interval of serum selenium and SePP concentration and GPx3 activity over genotypes of SNPs in selected selenoproteins in healthy participants of the EPIC-Heidelberg nested case-control study

NSerum Se concentration (μg/L)*PNSerum SePP concentration (mg/L)*PNSerum GPx3 activity (units/L)*P
SEP15 G1125A (rs5859)
GG30787.9 (86.4, 89.4)3082.91 (2.85, 2.96)309656.5 (644.4, 668.7)
GA15787.7 (85.6, 89.8)1572.96 (2.88, 3.04)157665.2 (648.1, 682.2)
AA2684.0 (78.9, 89.2)0.36262.83 (2.64, 3.03)0.3626607.7 (565.8, 649.7)0.05
SEP15 C>T (rs540049)
CC32388.0 (86.5, 89.5)3242.91 (2.85, 2.96)325655.9 (644.1, 667.8)
CT14287.5 (85.3, 89.7)1422.97 (2.88, 3.05)142666.9 (649.0, 684.9)
TT2584.2 (78.9, 89.4)0.38252.83 (2.63, 3.04)0.3325609.2 (566.4, 652.0)0.05
SEPP1 G>A coding (rs3877899)
GG27088.1 (86.5, 89.7)2712.95 (2.89, 3.01)271659.2 (646.1, 672.2)
GA19387.5 (85.7, 89.4)1932.90 (2.82, 2.97)194652.5 (637.0, 667.9)
AA2783.6 (78.6, 88.7)0.25272.83 (2.64, 3.03)0.4027662.8 (621.4, 704.3)0.77
SEPP1 G>A 3′UTR (rs7579)
GG25087.1 (85.4, 88.7)2502.87 (2.81, 2.94)250651.8 (638.2, 665.4)
GA20788.7 (86.8, 90.5)2082.98 (2.91, 3.05)209664.3 (649.4, 679.2)
AA3385.8 (81.2, 90.4)0.31332.89 (2.71, 3.06)0.0733645.9 (608.6, 683.3)0.40
GPX1 C>T (rs1050450)
CC26387.9 (86.2, 89.5)2642.95 (2.88, 3.01)264655.1 (641.8, 668.4)
CT18087.7 (85.7, 89.6)1802.91 (2.84, 2.99)181661.0 (644.9, 677.0)
TT4286.8 (82.7, 90.9)0.89422.82 (2.67, 2.98)0.3342643.5 (610.1, 676.9)0.63
GPX4 C718T (rs713041)
CC15587.8 (85.7, 89.9)1552.97 (2.89, 3.05)156663.8 (646.6, 681.1)
CT22887.1 (85.4, 88.8)2292.86 (2.80, 2.93)229651.2 (637.0, 665.5)
TT10588.3 (85.8, 90.9)0.711052.97 (2.87, 3.06)0.07105658.4 (637.4, 679.4)0.54
  • *Values are mean and (95% CI) adjusted for matching factors (age group and time of blood collection).

  • P values for difference derived from generalized linear models.