Genotype frequencies of selected polymorphisms in selenoproteins and association with prostate cancer risk in the EPIC-Heidelberg nested case-control study
| Gene SNP (rsNo.) | Genotype | Cases (%) | Controls (%) | HWE* | OR† | 95% CI |
|---|---|---|---|---|---|---|
| SEP15 | GG | 165 (66.5) | 309 (62.8) | 1.00 | ||
| G1125A | GA | 78 (31.5) | 157 (31.9) | 0.84 | (0.60, 1.17) | |
| (rs5859) | AA | 5 (2.0) | 26 (5.3) | |||
| 0.31 | ||||||
| SEP15 | CC | 165 (66.5) | 325 (66.1) | 1.00 | ||
| C>T | CT | 78 (31.5) | 142 (28.9) | 0.98 | (0.70, 1.37) | |
| (rs540049) | TT | 5 (2.0) | 25 (5.1) | |||
| 0.07 | ||||||
| SEPP1 | GG | 152 (61.3) | 271 (55.1) | 1.00 | ||
| G>A coding | GA | 86 (34.7) | 194 (39.4) | 0.80 | (0.58, 1.10) | |
| Ala234Thr | AA | 10 (4.0) | 27 (5.5) | 0.66 | (0.31, 1.39) | |
| (rs3877899) | 0.31 | |||||
| SEPP1 | GG | 116 (46.8) | 250 (50.8) | 1.00 | ||
| G>A 3′UTR | GA | 105 (42.3) | 209 (42.5) | 1.08 | (0.78, 1.49) | |
| (rs7579) | AA | 27 (10.9) | 33 (6.7) | 1.72 | (0.99, 2.98) | |
| 0.22 | ||||||
| GPX1 | CC | 123 (49.8) | 264 (54.2) | 1.00 | ||
| C>T | CT | 108 (43.7) | 181 (37.2) | 1.30 | (0.95, 1.78) | |
| Pro198Leu | TT | 16 (6.5) | 42 (8.6) | 0.81 | (0.44, 1.49) | |
| (rs1050450) | 0.18 | |||||
| GPX4 | CC | 77 (31.4) | 156 (31.8) | 1.00 | ||
| C718T | CT | 114 (46.5) | 229 (46.7) | 1.00 | (0.70, 1.44) | |
| (rs713041) | TT | 54 (22.0) | 105 (21.4) | 1.03 | (0.68, 1.57) | |
| 0.22 |