Table 3.

Association of each selected single-nucleotide polymorphisms at 8q24 with pathologic T stage (adjusted by age and prostate-specific antigen)

Risk locusSNPGenotypeUnivariateAdjusted by ageAdjusted by PSA
nOR (95% CI)PnOR (95% CI)PnOR (95% CI)P
1Rs1447295 (A)970.0831900.0569850.0894
CC111
CA2.177 (0.904-5.242)0.02842.614 (1.041-6.565)0.02242.275 (0.888-5.824)0.0307
AA0.458 (0.089-2.373)0.15050.537 (0.099-2.923)0.18940.446 (0.079-2.532)0.1560
2Rs6983561 (C)990.6464910.8596860.9530
AA111
CA1.497 (0.519-4.322)0.74811.363 (0.444-4.181)0.68751.147 (0.370-3.561)0.9272
CC1.714 (0.537-5.476)0.47131.300 (0.384-4.398)0.82691.213 (0.352-4.184)0.8018
Rs13254738 (C)950.7639880.6443830.8208
AA111
CA0.644 (0.184-2.246)0.46850.549 (0.147-2.049)0.35790.658 (0.178-2.429)0.5923
CC0.795 (0.223-2.840)0.98520.713 (0.182-2.784)0.93750.723 (0.188-2.784)0.8191
Broad11934905 (A)989085
GG111
AG4.481 (1.415-14.196)0.01083.301 (1.021-10.673)0.04613.524 (1.079-11.508)0.0370
3Rs6983267 (G)958883
GT111
GG1.153 (0.430-3.095)0.77691.359 (0.479-3.861)0.56441.270 (0.446-3.619)0.6545
Rs7000448 (T)98 0.80591 0.876486 0.6881
CC111
TC1.452 (0.394-5.353)0.74661.154 (0.325-4.096)0.96741.451 (0.377-5.588)0.8873
TT1.575 (0.404-6.145)0.57831.381 (0.363-5.247)0.60811.842 (0.450-7.542)0.4043

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.