Table 4.

Association of CASP8 D302H with breast and ovarian cancer risk

CASP8 D302HHR (95% CI)P*
Per-rare alleleHeterozygotesRare homozygotes
Breast cancer
    BRCA10.85 (0.76-0.97)0.83 (0.72-0.95)0.86 (0.56-1.31)0.028
    BRCA21.06 (0.88-1.27)1.04 (0.84-1.30)1.20 (0.62-2.33)0.794
Ovarian cancer
    BRCA10.69 (0.53-0.89)0.73 (0.55-0.98)0.31 (0.10-0.94)0.008
    BRCA21.27 (0.73-2.23)1.25 (0.67-2.34)1.94 (0.25-15.24)0.718
  • *Two–degree of freedom test.

  • Versus common homozygotes.