Table 2.

Characteristics of study subjects genotyped for the CASP8 D302H and CASP10 V410I polymorphisms

CharacteristicCASP8 D302HCASP10 V410I
TotalBRCA1BRCA2TotalBRCA1BRCA2
Carriers7,3534,8442,5097,2274,6942,533
Breast cancer
    Not affected
        No.3,3022,2411,0613,3552,2451,110
        Age at censure (mean ± SD)43.0 ± 12.642.7 ± 12.543.8 ± 12.943.3 ± 12.642.8 ± 12.444.1 ± 13.0
    Affected
        No.4,0512,6031,4483,8722,4491,423
        Age at event (mean ± SD)42.0 ± 9.740.8 ± 9.444.2 ± 9.942.1 ± 9.740.8 ± 9.444.3 ± 9.9
Ovarian cancer
    Not affected
        No.6,6284,2682,3606,5034,1222,381
        Age at censure (mean ± SD)41.6 ± 10.940.6 ± 10.743.3 ± 10.941.7 ± 11.040.7 ± 10.843.5 ± 11.0
    Affected
        No.725576149724572152
        Age at event (mean ± SD)50.6 ± 9.949.4 ± 9.555.6 ± 9.950.8 ± 10.049.4 ± 9.556.0 ± 10.0