Table 2.

ORs and 95% CIs for the association of plasma levels of 25(OH)D with the risk of colorectal cancer

25(OH)DCasesControlsOR* (95% CI)OR (95% CI)
<16.8 ng/mL67871.00 (Reference)1.00 (Reference)
16.8 to <22.242860.61 (0.37-1.02)0.63 (0.37-1.08)
22.2 to <26.338880.52 (0.31-0.89)0.54 (0.32-0.93)
26.3 to <32.843870.58 (0.34-0.99)0.62 (0.36-1.07)
≥32.839860.53 (0.30-0.93)0.60 (0.33-1.07)
Per doubling0.65 (0.48-0.86)0.68 (0.51-0.92)
Ptrend = 0.003Ptrend = 0.01
  • *Controlled for age, sex, race/ethnicity, study area, date and time of blood draw, and hours fasting through case-control matching and adjusted using conditional logistic regression.

  • Further adjusted for family history of colon cancer, BMI, and intake of processed red meat.

  • Trend tests based on the significance of the continuous variable, the logarithm (base 2) of 25(OH)D.