Table 4.

HRs and 95% CIs for colon cancer in relation to weight change by tumor subsite

Weight change categoryMenWomen
CasesHR (95% CI)*CasesHR (95% CI)*
Proximal
    ≤−3 kg51.04 (0.35-3.08)90.72 (0.32-1.59)
    >−3 to <3 kg (reference)111.00241.00
    3 to <10 kg311.37 (0.69-2.71)390.73 (0.44-1.20)
    10 to <20 kg501.63 (0.85-3.10)540.73 (0.46-1.18)
    ≥20 kg412.12 (1.10-4.10)440.86 (0.53-1.40)
    Linear model (per 5 kg)1381.14 (1.03-1.25)1701.01 (0.92-1.10)
    P for trend (linear model)<0.010.89
Distal
    ≤−3 kg20.36 (0.09-1.53)71.31 (0.49-3.52)
    >−3 to <3 kg (reference)151.00111.00
    3 to <10 kg240.69 (0.36-1.32)291.17 (0.59-2.33)
    10 to <20 kg410.78 (0.42-1.44)300.92 (0.46-1.82)
    ≥20 kg411.11 (0.58-2.11)241.07 (0.53-2.18)
    Linear model (per 5 kg)1231.09 (0.97-1.22)1010.98 (0.88-1.10)
    P for trend (linear model)0.140.72
  • *Adjusted for country of birth, weight at age 18 and height at study entry, education, processed and fresh meat consumption, fruit and vegetable consumption, fat intake, daily energy intake, smoking status, and alcohol consumption and stratified by tumor subsite.

  • Test for heterogeneity in the HRs for weight change between proximal and distal subsite: P = 0.59 (men) and P = 0.72 (women).