Men | Women | |||
---|---|---|---|---|

Cases (PY) | HR (95% CI)^{*} | Cases (PY) | HR (95% CI)^{*} | |

Weight at age 18 y (quartiles) | ||||

<61 kg/<50 kg | 73 (56,370) | 1.00 | 60 (72,766) | 1.00 |

61 to <67 kg/50 to <54 kg | 61 (58,551) | 0.79 (0.55-1.11) | 81 (80,481) | 1.24 (0.88-1.73) |

67 to <73 kg/54 to <59 kg | 70 (52,479) | 1.00 (0.70-1.41) | 62 (85,169) | 0.93 (0.64-1.34) |

≥73/≥59 kg | 73 (54,206) | 1.05 (0.72-1.51) | 89 (94,561) | 1.25 (0.88-1.79) |

Linear model (per 5 kg)^{†} | 277 (221,606) | 1.03 (0.94-1.12) | 292 (332,977) | 1.03 (0.94-1.14) |

P for trend (linear model) | 0.54 | 0.50 | ||

Weight at study entry (quartiles) | ||||

<73.0 kg/<59.8 kg | 50 (55,504) | 1.00 | 67 (83,762) | 1.00 |

73.0 to <79.8 kg/59.8 to <66.3 kg | 63 (55,853) | 1.23 (0.84-1.80) | 81 (83,009) | 1.24 (0.89-1.72) |

79.8 to <87.6 kg/66.3 to <74.7 kg | 78 (55,662) | 1.56 (1.08-2.28) | 61 (83,311) | 0.93 (0.65-1.33) |

≥87.6 kg/≥74.7 kg | 86 (54,587) | 1.81 (1.22-2.68) | 83 (82,896) | 1.32 (0.93-1.86) |

Linear model (per 5 kg)^{†} | 277 (221,606) | 1.12 (1.04-1.21) | 292 (332,977) | 1.04 (0.98-1.11) |

P for trend (linear model) | <0.01 | 0.22 | ||

BMI at age 18 y | ||||

<18.5 kg/m^{2} | 18 (11,012) | 1.46 (0.89-2.40) | 28 (42,291) | 0.79 (0.53-1.18) |

18.5 to <23 kg/m^{2} (reference) | 135 (118,562) | 1.00 | 180 (205,695) | 1.00 |

23 to <25 kg/m^{2} | 70 (53,675) | 1.08 (0.81-1.45) | 53 (50,366) | 1.18 (0.87-1.61) |

≥25 kg/m^{2} | 54 (38,358) | 1.21 (0.88-1.67) | 31 (34,625) | 1.07 (0.73-1.58) |

Linear model (per 5 kg/m^{2})^{†} | 277 (221,606) | 1.05 (0.80-1.37) | 292 (332,977) | 1.19 (0.93-1.52) |

P for trend (linear model) | 0.73 | 0.16 | ||

BMI at study entry | ||||

<23 kg/m^{2} | 13 (22,766) | 0.60 (0.32-1.13) | 64 (75,853) | 0.95 (0.67-1.36) |

23 to <25 kg/m^{2} (reference) | 38 (38,972) | 1.00 | 59 (63,349) | 1.00 |

25 to <30 kg/m^{2} | 160 (118,719) | 1.31 (0.91-1.87) | 102 (121,574) | 0.84 (0.61-1.17) |

≥30 kg/m^{2} | 66 (41,150) | 1.51 (1.00-2.28) | 67 (72,201) | 1.00 (0.70-1.44) |

Linear model (per 5 kg/m^{2})^{†} | 277 (221,606) | 1.39 (1.12-1.71) | 292 (332,977) | 1.01 (0.86-1.18) |

P for trend (linear model) | <0.01 | 0.90 |

Abbreviation: PY, person-years.

↵*Models adjusted for country of birth, education, processed and fresh meat consumption, fruit and vegetable consumption, fat intake, daily energy intake, smoking status, and alcohol consumption and stratified by sex. Models with weight at age 18 y or weight at study entry were also adjusted for height at study entry.

↵

^{†}Test for heterogeneity in the HRs between men and women, for weight at age 18 y (*P*= 0.92), weight at study entry (*P*= 0.12), BMI at age 18 y (*P*= 0.49), and BMI at study entry (*P*= 0.02).