Table 5.

Distribution of genotypes by cancer site, and their associations with colorectal cancer risk

SNPColorectal cancer-AllColonRectal
Cases/ControlsOR (95% CI)Cases/ControlsOR (95% CI)Cases/ControlsOR (95% CI)
CBS 699CC583/1,0561356/7021226/3611
CT603/1,0401.04 (0.90-1.21)374/6561.12 (0.94-1.35)230/3890.93 (0.74-1.18)
TT141/2531.00 (0.79-1.26)83/1481.11 (0.82-1.50)58/1030.87 (0.60-1.25)
Ptrend0.780.250.39
CBS ins0 ins1,233/2,1501761/1,3671472/7831
1 ins212/3581.02 (0.85-1.23)137/2311.04 (0.83-1.31)75/1271.00 (0.73-1.36)
2 ins9/180.89 (0.40-2.00)4/120.65 (0.21-2.04)5/61.29 (0.39-4.34)
Ptrend0.890.960.87
TCN2 67AA1,026/1,7891622/1,1471406/6491
AG263/4900.95 (0.80-1.12)162/3120.98 (0.79-1.21)100/1810.87 (0.66-1.15)
GG19/180.87 (0.50-1.53)13/221.03 (0.51-2.08)5/160.54 (0.20-1.51)
Ptrend0.420.880.15
TCN2 776CC415/7491253/4821162/2731
CG648/1,1700.99 (0.85-1.16)401/7620.99 (0.81-1.20)248/4121.01 (0.78-1.30)
GG266/4351.10 (0.90-1.33)160/2661.13 (0.88-1.46)105/1691.04 (0.76-1.43)
Ptrend0.450.420.81

NOTE: Wild type is the reference category.