Table 4.

Adjusted relative risks (95% CI) for colorectal cancer by quintiles of indices for vitamins B2, B6, and B12 status by alcohol consumption and sex

AlcoholCases/ControlsQ1Q2Q3Q4Q5Ptrend*PinteractionPinteraction
Vitamin B2 sum
    OverallAbstainer1-15s83/14410.88 (0.30-2.54)1.51 (0.48-4.72)1.01 (0.31-3.23)1.06 (0.31-3.72)0.82
1-30 g/d939/167110.83 (0.63-1.09)0.92 (0.70-1.20)0.85 (0.65-1.12)0.83 (0.63-1.09)0.27
≥30 g/d274/36010.55 (0.33-0.92)0.65 (0.39-1.10)0.60 (0.34-1.04)0.56 (0.32-0.98)0.070.21
    Males1-30 g/d386/70010.80 (0.53-1.22)1.23 (0.82-1.85)1.16 (0.76-1.76)0.87 (0.56-1.35)0.82
≥30 g/d220/28510.50 (0.28-0.89)0.66 (0.37-1.19)0.76 (0.41-1.40)0.50 (0.26-0.96)0.150.14
    Females1-30 g/d553/97110.84 (0.58-1.20)0.75 (0.52-1.08)0.69 (0.48-0.99)0.80 (0.57-1.14)0.170.27
≥30 g/d54/7510.58 (0.14-2.40)0.53 (0.14-1.94)0.20 (0.04-0.99)0.52 (0.15-1.80)0.220.550.91
Vitamin B6 sum
    OverallAbstainer1-15s86/14910.53 (0.20 1.41)0.73 (0.27-1.96)1.04 (0.39-2.80)0.39 (0.11-1.39)0.54
1-30 g/d940/169110.92 (0.71-1.18)0.78 (0.60-1.02)0.91 (0.70- 1.19)0.76 (0.58-1.01)0.09
≥30 g/d272/35710.94 (0.49-1.80)0.91 (0.47-1.76)0.70 (0.37-1.35)0.55 (0.28-1.07)0.030.12
    Males1-30 g/d392/71811.18 (0.77-1.80)0.80 (0.52-1.23)1.17 (0.77-1.77)0.80 (0.51-1.26)0.44
≥30 g/d218/28210.56 (0.25-1.25)0.50 (0.22-1.13)0.41 (0.19-0.91)0.34 (0.15-0.76)0.010.01
    Females1-30 g/d548/97310.79 (0.58-1.08)0.80 (0.57-1.12)0.77 (0.54-1.10)0.76 (0.53-1.09)0.140.50
≥30 g/d54/7512.21 (0.52-9.36)1.79 (0.40-8.07)3.19 (0.67-15.20)0.92 (0.19-4.49)0.860.340.03
Cobalamin
    OverallAbstainer1-15s88/15410.36 (0.12-1.11)0.77 (0.27-2.26)0.75 (0.28-2.01)0.56 (0.21-1.53)0.66
1-30 g/d959/170810.94 (0.73-1.22)1.10 (0.86-1.42)1.06 (0.82-1.38)1.05 (0.80-1.37)0.49
≥30 g/d275/36310.76 (0.46-1.26)0.68 (0.41-1.15)1.00 (0.60-1.68)0.93 (0.54-1.60)0.910.76
    Males1-30 g/d401/72210.97 (0.67-1.41)1.27 (0.88-1.83)1.11 (0.75-1.66)1.07 (0.69-1.65)0.48
≥30 g/d221/28910.93 (0.53-1.64)0.73 (0.41-1.31)1.07 (0.59-1.96)0.99 (0.53-1.84)0.930.66
    Females1-30 g/d558/98610.89 (0.62-1.29)0.96 (0.68-1.37)1.03 (0.73-1.45)1.00 (0.71-1.41)0.720.76
≥30 g/d54/7410.45 (0.11-1.76)0.58 (0.14-2.31)0.73 (0.22-2.45)0.71 (0.19-2.59)0.800.900.78
MMA
    OverallAbstainer1-15s88/15511.16 (0.45-2.96)1.97 (0.68-5.73)0.92 (0.33-2.59)1.20 (0.43-3.36)0.93
1-30 g/d961/171411.07 (0.82-1.40)1.10 (0.85-1.43)1.17 (0.90-1.53)0.91 (0.69-1.21)0.80
≥30 g/d276/36511.45 (0.88-2.39)1.28 (0.75-2.17)1.28 (0.76-2.17)1.28 (0.73-2.27)0.530.63
    Males1-30 g/d400/72311.19 (0.79-1.81)1.33 (0.88-2.03)1.22 (0.80-1.85)1.01 (0.66-1.54)0.98
≥30 g/d222/29011.62 (0.92-2.84)1.56 (0.86-2.84)1.49 (0.83-2.69)1.51 (0.81-2.83)0.240.40
    Females1-30 g/d561/99111.01 (0.71-1.43)0.98 (0.70-1.37)1.19 (0.84-1.68)0.86 (0.59-1.24)0.800.98
≥30 g/d54/7511.30 (0.37-4.61)0.58 (0.13-2.52)0.87 (0.23-3.28)0.72 (0.14-3.67)0.520.320.31

NOTE: Counts do not necessarily add to the total sum due to missing data.

The lower quintile is reference category. All analyses are matched for age, sex, study center, and date of blood collection and further adjusted for smoking status, education level, physical activity, fiber intake, intake of red and processed meat, alcohol consumption, and BMI.

The cutoff values for the quintiles of vitamin B2 sum were 14.2, 18.1, 23.5, and 33.4 μmol/L; for the vitamin B6 sum they were 45.4, 57.7, 72.6, and 105.3 μmol/L; for vitamin B12 they were 220, 266, 312, and 380 pmol/L; and for MMA they were 0.14, 0.16, 0.18, and 0.22 μmol/L.

  • *Ptrend (two-sided) in risk calculated with conditional logistic regression models with the covariates in the model using values for quintile categories as the quantitative score of exposure.

  • Pinteraction (two-sided) of the vitamin-colorectal cancer association by alcohol consumption (abstainers excluded) for the overall model, and separately for males and females.

  • Pinteraction (two-sided) of the vitamin-colorectal cancer association by sex, separately for individuals with low alcohol consumption (abstainers excluded) and high alcohol consumption.