Table 2.

Median concentrations (5th-95th percentile) of indices for vitamin B2, B6, and B12 by demographic and lifestyle characteristics in control cohort members (n = 2,319)

nVitamin B2 indicesVitamin B6 indicesVitamin B12 indices
Vitamin B2 sum (nmol/L)Riboflavin (nmol/L)FMN (nmol/L)Vitamin B6 sum (nmol/L)PLP (nmol/L)PL (nmol/L)PA (nmol/L)Cobalamin (pmol/L)MMA (μmol/L)
SexMale1,10519.2 (9.5-71.3)13.4 (5.6-58.9)5.3 (2.2-17.9)69.5 (33.5-190.5)35.6 (15.1-97.4)13.8 (6.8-36.1)18.4 (8.5-56.5)274 (154-467)0.17 (0.12-0.32)
Female1,21321.8 (10.9-77.0)16.2 (6.9-64.5)5.4 (2.0-15.7)60.5 (31.1-288.5)31.2 (13.4-130.0)13.1 (6.6-58.1)15.2 (7.3-106)303 (170-517)0.17 (0.11-0.31)
Pdifference*<0.001<0.0010.60<0.001<0.0010.10<0.001<0.0010.49
Age<60 years1,27420.0 (9.8-73.3)13.8 (5.9-58.9)5.7 (2.2-16.4)62.9 (32.1-217.8)33.9 (14.7-115.0)12.8 (6.5-41.9)15.6 (7.5-67.0)294 (167-488)0.16 (0.11-0.27)
≥60 years1,04421.4 (10.4-74.7)15.9 (6.8-64.2)4.9 (2.0-15.8)66.2 (32.1-228.2)32.8 (13.8-105.0)13.9 (6.9-45.9)17.7 (8.3-81.8)279 (153-506)0.18 (0.12-0.35)
Pdifference*<0.005<.001<0.0010.210.02<0.005<0.001<0.005<0.001
RegionNorth73123.4 (12.3-83.1)16.6 (6.8-64.2)6.5 (3.1-16.3)75.0 (34.0-328.6)36.9 (14.3-141.5)16.2 (6.5-76.0)21.1 (8.9-125)290 (166-478)0.17 (0.12-0.31)
Central99921.5 (10.8-80.9)16.0 (7.4-66.2)4.8 (1.9-16.5)65.4 (32.4-211.3)33.0 (14.8-110.0)13.6 (7.3-37.1)16.3 (8.1-64.8)276 (161-481)0.18 (0.12-0.32)
South58816.3 (8.1-64.0)11.2 (4.8-51.5)4.9 (2.0-14.9)55.2 (28.6-115.4)29.9 (13.3-73.2)11.0 (6.2-22.9)13.5 (6.5-29.6)304 (160-550)0.16 (0.11-0.31)
Pdifference<0.001<0.001<.001<0.001<0.001<0.001<0.001<0.001<0.001
SmokingNever1,02421.8 (11.2-83.4)16.3 (7.0-68.7)5.5 (2.1-16.5)65.4 (33.3-225.9)34.2 (15.5-109.0)13.7 (7.2-47.0)16.5 (8.1-75.9)296 (166-503)0.17 (0.12-0.30)
Former77421.0 (9.6-87.7)15.0 (6.3-71.8)5.3 (2.1-16.8)69.1 (34.0-216.1)35.1 (15.5-120.0)14.2 (7.1-40.1)18.2 (8.5-71.0)283 (161-498)0.17 (0.12-0.32)
Current50718.4 (9.5-57.8)12.3 (5.1-47.0)5.4 (2.1-14.2)57 (26.5-220.6)28.9 (11.8-105.0)11.9 (5.4-41.6)14.7 (6.6-64.9)277 (147-482)0.16 (0.11-0.33)
Ptrend§<0.005<0.0050.220.910.050.760.78<0.0050.91
Alcohol (g/day)Abstainers16619.3 (8.9-87.6)14.3 (5.7-65.3)5.0 (2.2-15.0)59.4 (25.7-228.2)29.5 (12.2-120.0)13.2 (5.2-54.8)16.7 (6.8-83.5)321 (183-527)0.16 (0.11-0.32)
1-301,78421.0 (10.4-73.3)15.3 (6.5-62.6)5.3 (2.0-15.8)63.4 (32.0-227.9)32.2 (14.3-109.0)13.2 (6.6-44.7)16.3 (7.8-74.3)287 (161-496)00.17 (0.12-0.32)
≥3037219.4 (9.4-76.2)12.7 (5.4-53.7)6.0 (2.3-21.4)75.5 (35.2-207.7)41.7 (16.4-116.0)14.8 (7.7-38.4)19.2 (8.1-57.3)280 (162-481)0.16 (0.11-0.28)
Pdifference*0.03<0.001<0.005<0.001<0.001<0.0010.001<0.005<0.005
  • *Pdifference (two-sided) calculated by Mann Whitney U test; abstainers were excluded from statistical analyses on alcohol consumption.

  • North: Sweden and Denmark; Central: United Kingdom.

  • Pdifference (two-sided) calculated by Kruskall Wallis test.

  • §Ptrend (two-sided) calculated by regression models.