Table 1.

Characteristics of incident colorectal cancer cases and their matched controls

CasesControlsPdifference
Number of individuals1,3652,319
Sex, female, n (%)697 (51)1213 (52)0.54
Mean age in years (min-max)
    At recruitment58.9 (30.1-76.9)58.7 (30.0-76.6)0.40
    At blood donation59.1 (36.8-77.0)58.9 (36.6-76.6)0.44
    At diagnosis62.8 (37.7-81.2)N.a.
    Lag time3.6 (0.01-10.3)N.a.
Smoking status, n (%)0.02
    Never559 (41)1,024 (44)
    Former447 (33)774 (33)
    Current344 (25)508 (22)
Alcohol drinking, n (%)<0.01
    Abstainers93 (7)166 (7)
    1-30 g/day983 (72)1784 (77)
    ≥30 g/day281 (21)372 (16)
Median (5th-95th percentile)
    Vitamin B2 sum, nmol/L20.6 (9.4-65.7)20.6 (10.1-74.7)0.36
    Riboflavin, nmol/L14.8 (6.1-60.6)14.8 (5.9-53.7)0.37
    FMN, nmol/L5.4 (2.1-16.3)5.3 (1.9-15.3)0.20
    Vitamin B6 sum, nmol/L63 (31-197)65 (32-222)0.20
    PLP, nmol/L33.2 (14.2-111)32.1 (13.2-93.8)<0.01
    PL, nmol/L13.4 (6.7-44.0)13.1 (6.2-38.3)0.16
    PA, nmol/L16.5 (7.8-72.5)17.3 (7.8-74.3)0.17
    Cobalamin, pmol/L288 (162-498)288 (161-501)0.97
    MMA, μmol/L0.17 (0.12-0.32)0.17 (0.12-0.30)0.32

NOTE: Differences in plasma concentrations of the vitamins B2, B6, and B12, and MMA were assessed by Wilcoxon signed rank test, whereas categorical variable differences were assessed by McNemar's tests.

Abbreviation: N.a., not applicable.