Table 2.

Univariate associations between selected risk factors and baseline plasma Hcy

Characteristic*Baseline plasma homocysteine, μmol/L
≤7.957.96-9.269.27-11.25>11.25P
Mean age (SD)54.6 (9.3)58.1 (9.1)58.4 (9.6)58.9 (9.7)<0.001
Male (%)41.062.276.977.7<0.001
Current smoker (% yes)12.211.711.921.00.01
BMI (kg/m2) %/category
    1 (≤25 kg/m2)37.834.725.123.80.01
    2 (25-< 30 kg/m2)38.743.249.354.7
    3 (≥30 kg/m2)23.422.125.621.5
Alcohol drinker (% yes)62.070.167.773.90.06
Alcohol mean (SD), drinks/day among drinkers0.6 (0.8)0.9 (1.3)0.9 (0.9)1.2 (1.4)<0.001
Mean baseline plasma folate (SD), nmol/L31.0 (18.5)26.2 (16.6)20.7 (14.0)17.3 (17.6)<0.001
Mean baseline plasma B12 (SD), pmol/L371 (145)346 (210)309 (113)295 (163)<0.001
Mean baseline plasma B6 (SD), nmol/L107 (118)84 (87)73 (84)61 (57)<0.001
Mean baseline plasma B2 (SD), nmol/L36 (50)33 (61)27 (51)24 (43)<0.001
Number of adenomas at baseline exam, mean (SD)1.4 (0.8)1.5 (0.8)1.7 (1.2)1.7 (1.0)0.001
MTHFR 677 C>T genotype (% yes)
    CC49.545.249.037.90.11
    CT44.142.940.450.0
    TT6.412.010.612.1
  • *All risk factor values were taken from the baseline questionnaire.

  • Quartile cut points based on the distribution of plasma tHcy in the whole study population.

  • P for trend for continuous variables (age, number of alcohol drinks, plasma levels, number of baseline adenomas) or P for heterogeneity for categorical variables (sex, current smoker, BMI, alcohol drinker, MTHFR 677).