Table 5.

Relative risk (and 95% confidence interval) of endometrial and ovarian cancers by quintile of calorie-adjusted acrylamide intake additionally adjusting for high-acrylamide foods, 1980 to 2006

Quintile of calorie-adjusted acrylamide intakeP for trend
Q1 (low)Q2Q3Q4Q5 (high)
Endometrial cancer
    No. of cases8810010610288
    Person-years277,776277,073276,839277,409277,789
    MV RR*1.001.12 (0.83-1.50)1.31 (0.97-1.77)1.35 (0.99-1.84)1.41 (1.01-1.97)0.03
    MV RR + coffee1.001.08 (0.80-1.46)1.26 (0.93-1.72)1.31 (0.95.80)1.37 (0.97-1.94)0.05
    MV RR + cereal1.001.09 (0.81-1.47)1.27 (0.94-1.72)1.31 (0.95-1.79)1.37 (0.98-1.93)0.05
    MV RR + French fries1.001.16 (0.85-1.58)1.41 (1.02-1.95)1.51 (1.06-2.16)1.69 (1.11-2.57)0.01
    MV RR + potato chips1.001.11 (0.82-1.49)1.29 (0.94-1.75)1.32 (0.95-1.83)1.37 (0.95-1.97)0.06
Ovarian cancer
    No. of cases8775958178
    Person-years246,187245,523245,327245,667246,155
    MV RR1.000.93 (0.68-1.29)1.29 (0.94-1.76)1.17 (0.84-1.64)1.25 (0.88-1.77)0.12
    MV RR + coffee1.000.93 (0.67-1.29)1.29 (0.94-1.78)1.18 (0.83-1.65)1.24 (0.87-1.78)0.15
    MV RR + cereal1.000.92 (0.67-1.27)1.26 (0.92-1.73)1.15 (0.82-1.62)1.23 (0.86-1.76)0.15
    MV RR + French fries1.000.90 (0.64-1.25)1.24 (0.88-1.74)1.15 (0.78-1.68)1.29 (0.83-1.99)0.14
    MV RR + potato chips1.000.90 (0.65-1.24)1.18 (0.85-1.63)1.02 (0.72-1.46)1.01 (0.69-1.49)0.82
  • *Endometrial cancer multivariable models adjusted for age in months, calendar year, smoking (never, past <25 cigarettes per day, past ≥25 cigarettes per day, current <25 cigarettes per day, current ≥25 cigarettes per day), BMI (<20, 20 to <21, 21 to <22, 22 to <23, 23 to <24, 24 to <25, 25 to <27, 27 to <29, 29 to <30, 30 to <32, 32 to <35, 35 to <40, ≥40 kg/m2), age at menarche (<13, 13, ≥14 y), menopausal status/age at menopause/PMH use (premenopausal; uncertain status; postmenopausal and age at menopause <45, 45-52, or >52 y; and PMH use never, former, current <5 y, or current ≥5 y), parity (nulliparous, 1-2, 3-4, ≥5), oral contraceptive use (never, 0-3, >3 to <5, ≥5 y of use), high blood pressure (yes/no), diabetes (yes/no), physical activity (≤18 or >18 MET-h/wk), caffeine intake (quintiles), and energy intake (continuous; kilocalories per day).

  • Adjusted as in multivariable model and additionally adjusted for intake of given food in quintiles (for acrylamide quintile analysis) or as a continuous variable using the median intake for each quintile (for acrylamide P for trend analysis).

  • Ovarian cancer multivariable models adjusted for age in months, calendar year, smoking (see categories for endometrial cancer), BMI (<18.5, 18.5 to <20, 20 to <22.5, 22.5 to <25, 25 to <30, ≥30 kg/m2), parity (see categories for endometrial cancer), oral contraceptive use (see categories for endometrial cancer), menopausal status and PMH use (premenopausal, uncertain status, postmenopausal and never used PMH, postmenopausal and former PMH, postmenopausal and current PMH use), tubal ligation (yes/no), physical activity (≤18 or >18 MET-h/wk), caffeine intake (quintiles), and energy intake (continuous; kilocalories per day).