Table 4.

Relative risk (and 95% confidence interval) of breast cancer and ovarian cancer subtypes by quintile of calorie-adjusted acrylamide intake

Quintile of calorie-adjusted acrylamide intakeP for trend
Q1 (low)Q2Q3Q4Q5 (high)
Breast cancer
    ER+/PR+ (n)520594606580505
    MV RR*1.000.98 (0.87-1.10)0.99 (0.88-1.12)0.99 (0.87-1.11)0.99 (0.87-1.13)0.99
    ER+/PR− (n)136161173148119
    MV RR*1.001.09 (0.87-1.38)1.20 (0.95-1.51)1.08 (0.85-1.37)1.04 (0.80-1.34)0.88
    ER−/PR+ (n)2823203532
    MV RR*1.000.78 (0.45-1.37)0.66 (0.37-1.20)1.18 (0.70-1.98)1.09 (0.63-1.87)0.35
    ER−/PR− (n)178159175174153
    MV RR*1.000.86 (0.69-1.07)0.94 (0.76-1.17)0.95 (0.77-1.19)0.88 (0.70-1.11)0.52
Ovarian cancer
    Invasive (n)7266887166
    MV RR1.000.98 (0.69-1.38)1.45 (1.03-2.03)1.28 (0.89-1.83)1.31 (0.89-1.92)0.09
    Borderline (n)1497912
    MV RR1.000.74 (0.31-1.77)0.57 (0.22-1.51)0.74 (0.29-1.87)0.99 (0.40-2.46)0.92
    Serous (n)4046545253
    MV RR1.001.11 (0.71-1.73)1.43 (0.92-2.22)1.39 (0.88-2.20)1.58 (0.99-2.52)0.04
    Serous Invasive (n)3339484443
    MV RR1.001.14 (0.70-1.86)1.59 (0.99-2.57)1.52 (0.92-2.51)1.67 (0.99-2.81)0.04

Abbreviation: cum. avg., cumulative average.

  • *Breast cancer models adjusted for age in months, calendar year, smoking (never, past <25 cigarettes per day, past ≥25 cigarettes per day, current <25 cigarettes per day, current ≥25 cigarettes per day), BMI (<18.5, 18.5 to <20, 20 to <22.5, 22.5 to <25, 25 to <30, ≥30 kg/m2), height (quartiles), parity and age at first birth (nulliparous, parity 1-2 and age at first birth <25 y, parity 1-2 and age at first birth 25 to <30 y, parity 1-2 and age at first birth ≥30 y, parity 3-4 and age at first birth <25 y, parity 3-4 and age at first birth 25 to <30 y, parity 3-4 and age at first birth ≥30 y, parity ≥5 and age at first birth <25 y, parity ≥5 and age at first birth ≥25 y), family history of breast cancer (yes/no), benign breast disease (yes/no), age at menarche (<13, 13, ≥14 y), physical activity (≤18 or >18 MET-h/wk), folate, glycemic index, and animal fat intake (quintiles), alcohol (continuous; grams per day), and energy intake (continuous; kilocalories per day). Postmenopausal model adjusted for joint age at menopause and PMH use variable (age at menopause <45, 45-52, or >52 y AND PMH use never, former, current <5 y, or current ≥5 y).

  • Ovarian cancer models adjusted for age in months, calendar year, smoking (see categories for breast cancer), BMI (see categories for breast cancer), parity (nulliparous, 1-2, 3-4, ≥5), oral contraceptive use (never, 0-3, >3 to <5, ≥5 y of use), menopausal status and PMH use (premenopausal, uncertain status, postmenopausal and never used PMH, postmenopausal and former PMH, postmenopausal and current PMH use), tubal ligation (yes/no), physical activity (≤18 or >18 MET-h/wk), caffeine intake (quintiles), and energy intake (continuous; kilocalories per day).