Table 3.

Conditional logistic regression showing odds ratios and 95% confidence interval of cancer in situ and invasive squamous cell carcinoma in the first and last smears among HPV-positive women

Reference: all other women*Reference: HPV negative women*
OR (95% CI)OR (95% CI)
First smearLast smearFirst smearLast smear
Cancer in situ
HPV16/186.2 (4.2-9.2)22.5 (12.3-41.1)8.5 (5.3-13.7)37.1 (18.1-76.1)
Non-16/18 HRHPV3.5 (2.4-5.0)8.4 (5.4-13.1)4.4 (2.8-6.8)15.8 (8.3-30.1)
LRHPV1.8 (1.0-3.1)2.0 (1.1-3.7)2.6 (0.97-6.8)5.0 (1.4-17.9)
Squamous cell carcinoma
HPV16/1812.9 (6.8-24.6)15.1 (8.0-28.6)18.6 (9.0-38.9)28.5 (13.0-62.4)
Non-16/18 HRHPV2.0 (1.3-3.1)4.6 (2.7-7.8)3.0 (1.6-5.5)16.9 (6.8-42.1)
LRHPV0.9 (0.4-2.1)0.7 (0.3-1.6)1.3 (0.4-4.5)0.8 (0.1-4.8)

NOTE: Non-16/18 HRHPV denotes any high-risk HPV infection apart from HPV16 or HPV18.

  • *All estimates were controlled for matching criteria (county, date of entry into cohort, and age at first normal smear).

  • ORs further adjusted for all other HPV variables.