Table 3.

Association between CYP24A1 haplotypes and colon cancer among non-Hispanic whites

HaplotypeControls %All colon cancerProximal colon cancerDistal colon cancer
Cases %OR* (95% CI)PCases %OR* (95% CI)PCases %OR* (95%CI)P
Block 1 (IVS7 + 921C > T, IVS7 + 1307A > T, IVS9 + 198T > C)
    C-A-T39.438.01.0039.21.0037.11.00
    T-A-C31.132.31.07 (0.95-1.20)0.2930.60.98 (0.84-1.15)0.8334.21.15 (0.99-1.33)0.07
    T-T-T17.415.80.94 (0.81-1.08)0.3916.50.95 (0.79-1.14)0.5615.20.93 (0.77-1.12)0.42
    T-A-T8.69.41.14 (0.95-1.38)0.169.51.14 (0.90-1.43)0.289.01.11 (0.88-1.41)0.37
    rare1.32 (1.01-1.73)0.051.23 (0.87-1.72)0.241.40 (1.01-1.95)0.05
Global P0.270.780.16
  • *Among non-Hispanic whites adjusted for age, sex and study center.

  • Loci of SNPs included in Block 1 are in the following order: rs2762938, rs2762936, rs1570669.