Table 2.

Odds ratios and 95% confidence intervals for the association between polymorphisms in CYP24A1 and CYP27B1 and colon cancer risk

Position/GenotypeMAF (%)*Controls (n)All colon cancerProximal colon cancerDistal colon cancer
Cases (n)OR (95%CI)P for trendCases (n)OR (95%CI)P for trendCases (n)OR (95%CI)P for trend
CYP24A1
IVS1-105G > C (rs2248137)0.401
    GG6875461.002691.002601.00
    CG8627091.01 (0.87-1.18)3471.01 (0.84-1.23)3471.04 (0.86-1.25)
    CC3322861.01 (0.83-1.23)0.911270.93 (0.72-1.20)0.661531.11 (0.87-1.42)0.41
    CC + CG vs. GG1.01 (0.88-1.17)0.99 (0.83-1.19)1.06 (0.88-1.26)
IVS2 + 523C > T (rs2762942)0.062
    TT1,7121,4301.006911.007021.00
    TC2141490.85 (0.68-1.06)700.82 (0.62-1.10)770.90 (0.68-1.19)
    CC920.26 (0.06-1.19)0.050-0.0620.52 (0.11-2.41)0.31
    CC + TC vs. TT0.83 (0.66-1.03)0.79 (0.59-1.05)0.88 (0.67-1.16)
IVS2-105A > G (rs2259735)0.416
    AA6625101.002491.002451.00
    AG8957561.08 (0.93-1.25)3761.11 (0.91-1.34)3631.07 (0.88-1.30)
    GG3633081.03 (0.84-1.25)0.671350.94 (0.73-1.21)0.881671.13 (0.89-1.44)0.30
    GG + AG vs. AA1.06 (0.92-1.23)1.06 (0.89-1.27)1.09 (0.91-1.30)
IVS3 + 103T > C (rs6022999)0.236
    TT1,1129331.004441.004631.00
    TC6925380.90 (0.78-1.04)2730.97 (0.81-1.16)2540.85 (0.71-1.02)
    CC1281201.00 (0.76-1.32)0.37500.89 (0.62-1.28)0.55681.11 (0.79-1.55)0.51
    CC + TC vs. TT0.92 (0.80-1.05)0.96 (0.81-1.14)0.89 (0.75-1.05)
IVS4 + 1653C > T (rs2181874)0.243
    CC1,1059211.004121.004851.00
    CT7135760.95 (0.83-1.10)3111.15 (0.97-1.37)2550.80 (0.67-0.95)
    TT123980.95 (0.71-1.26)0.49461.00 (0.70-1.43)0.32470.86 (0.60-1.23)0.03
TT + CT vs. CC0.95 (0.83-1.09)1.13 (0.95-1.34)0.81 (0.68-0.96)
IVS4-66T > G (rs4809958)0.174
    TT1,3141,1441.005551.005621.00
    GT5533970.82 (0.71-0.96)1960.84 (0.69-1.01)1930.82 (0.67-0.99)
    GG49390.92 (0.60-1.42)0.03120.59 (0.31-1.12)0.02251.19 (0.73-1.96)0.21
    GG + GT vs. TT0.83 (0.72-0.96)0.82 (0.68-0.99)0.85 (0.70-1.02)
IVS5-162T > C (rs6013905)0.169
    TT1,2961,1201.005431.005501.00
    CT5143780.85 (0.72-0.99)1850.86 (0.70-1.04)1860.85 (0.70-1.03)
    CC52410.91 (0.60-1.38)0.06130.60 (0.33-1.12)0.04261.17 (0.72-1.90)0.35
    CC + CT vs. TT0.85 (0.73-0.99)0.83 (0.69-1.01)0.88 (0.73-1.06)
IVS5-149C > G (rs2762939)0.252
    CC1,0558761.004041.004481.00
    GC7405860.94 (0.82-1.08)3001.06 (0.89-1.26)2730.85 (0.71-1.02)
    GG1301181.04 (0.79-1.36)0.74591.14 (0.82-1.59)0.38570.97 (0.69-1.37)0.23
    GG + GC vs. CC0.96 (0.83-1.09)1.07 (0.90-1.27)0.87 (0.73-1.03)
IVS7 + 921C > T (rs2762938)0.410
    TT6545641.002611.002891.00
    TC9507710.95 (0.82-1.10)3841.02 (0.85-1.23)3690.89 (0.74-1.07)
    CC3252540.92 (0.75-1.12)0.371210.94 (0.73-1.21)0.711260.90 (0.70-1.15)0.28
    CC + TC vs. TT0.94 (0.82-1.08)1.00 (0.84-1.19)0.89 (0.75-1.06)
IVS7 + 1307A > T (rs2762936)0.199
    AA1,2111,0141.004841.005031.00
    TA6334870.90 (0.78-1.04)2420.95 (0.79-1.14)2340.87 (0.72-1.04)
    TT80791.13 (0.81-1.56)0.58371.12 (0.74-1.68)0.91411.17 (0.78-1.74)0.53
    TT + TA vs. AA0.93 (0.81-1.07)0.97 (0.81-1.15)0.90 (0.75-1.07)
IVS9 + 198T > C (rs1570669)0.340
    TT8306511.003211.003131.00
    CT8807141.02 (0.88-1.18)3491.01 (0.85-1.21)3491.03 (0.86-1.24)
    CC2252251.21 (0.97-1.50)0.15971.08 (0.82-1.42)0.661221.33 (1.03-1.73)0.07
    CC + CT vs. TT1.06 (0.92-1.21)1.02 (0.86-1.22)1.09 (0.92-1.29)
+4125bp 3′ of STP C > G (rs927648)0.242
    CC1,0828551.004101.004231.00
    GC7335951.01 (0.88-1.16)2911.04 (0.87-1.24)2931.00 (0.84-1.19)
    GG1151251.29 (0.98-1.70)0.21551.18 (0.84-1.68)0.40641.32 (0.95-1.85)0.29
    GG + GC vs. CC1.05 (0.91-1.20)1.06 (0.89-1.25)1.04 (0.88-1.23)
Global P0.100.240.13
CYP27B1
IVS6-29T > C (rs4646536)0.314
    TT9107291.003461.003671.00
    CT7966631.05 (0.91-1.21)3241.08 (0.90-1.29)3181.00 (0.84-1.19)
    CC1991701.08 (0.86-1.35)0.42801.06 (0.80-1.42)0.47881.11 (0.84-1.47)0.60
    CC + CT vs. TT1.06 (0.92-1.21)1.08 (0.91-1.28)1.02 (0.86-1.21)
  • *MAF (minor allelic frequency) calculated from results from genotyping restricted to non-Hispanic White controls.

  • Adjusted for age, race, sex and study center.