Meta-analysis results (all cases vs controls)
| Gene | Variant | SNP | Studies | Cases | Controls | Dominant effect (a/a | a/A) vs AA | Recessive effect aa vs (a/A | A/A) | Homozygous a/a vs A/A | Additive effect a/a, a/A vs A/A (ref) |
|---|---|---|---|---|---|---|---|---|---|
| Pooled odds ratio (95% CI)* | Pooled odds ratio (95% CI)* | Pooled odds ratio (95% CI) * | Pooled odds ratio (95% CI) * | ||||||
| MTHFR | 677C>T | rs1801133 | 12 | 10,745 | 40,158 | 1.04 (0.97-1.12) | 1.03 (0.86-1.22)† | 1.05 (0.89-1.23)‡ | 1.03 (0.98-1.09) |
| MTHFR | 1298A>C | rs1801131 | 5 | 3,176 | 4,829 | 0.96 (0.87-1.05) | 0.90 (0.77-1.05) | 0.89 (0.76-1.05) | 0.95 (0.89-1.02) |
| MTR | 2756A>G | rs1805087 | 8 | 7,810 | 37,543 | 1.06 (1.00-1.12) | 1.02 (0.88-1.19) | 1.04 (0.90-1.21) | 1.05 (0.99-1.10) |
| MTRR | 66A>G | rs1801394 | 4 | 3,032 | 4,515 | 0.95 (0.86-1.05) | 0.93 (0.76-1.13) | 0.93 (0.80-1.08) | 0.96 (0.90-1.03) |
| MTHFD1 | 1958G>A | rs2236225 | 6 | 7,493 | 36,941 | 1.01 (0.95-1.08) | 1.00 (0.93-1.07) | 1.01 (0.92-1.09) | 1.00 (0.96-1.05) |
| SLC19A1 | 80G>A | rs1051266 | 4 | 6,222 | 35,821 | 0.98 (0.92-1.05) | 1.02 (0.94-1.10) | 1.00 (0.91-1.09) | 1.00 (0.95-1.04) |
| SHMT1 | 1420C>T | rs1979277 | 2 | 2,689 | 4,110 | 1.11 (1.00-1.22) | 1.10 (0.93-1.28) | 1.15 (0.97-1.35) | 1.08 (1.00-1.16) |
| FOLH1 | 1561T>C | rs202676 | 5 | 6,314 | 35,190 | 1.00 (0.93-1.08) | 0.99 (0.86-1.13) | 0.99 (0.85-1.15) | 1.00 (0.93-1.07) |