Table 2.

Lifestyle and demographic factors and the risk for serrated polyps

Variablesn TotalSerrated polypsP differenceAdvanced serrated polypsP difference
LeftRightLeftRight
n CasesRR (95% CI)n CasesRR (95% CI)n CasesRR (95% CI)n CasesRR (95% CI)
Family history of polyps
    No1,9974611.01721.0561.00361.00
    Yes5211331.15 (0.96-1.40)601.39 (1.04-1.86)0.21210.98 (0.60-1.60)171.42 (0.82-2.43)0.07
Family history of colorectal cancer
    No1,8314351.01611.0481.0331.0
    Yes6871591.03 (0.88-1.22)711.21 (0.92-1.60)0.19291.24 (0.80-1.93)201.23 (0.74-2.06)0.22
Sex
    Male2,0094881.01811.0531.0441.0
    Female8211840.98 (0.84-1.14)801.07 (0.82-1.39)0.27341.35 (0.87-2.08)241.16 (0.72-1.87)0.65
Race
    White2,4126191.02351.0791.0641.0
    Black193310.59 (0.42-0.81)150.75 (0.44-1.27)40.54 (0.20-1.50)20.41 (0.11-1.55)
    Hispanic10570.31 (0.16-0.62)40.41 (0.15-1.09)30.57 (0.17-1.92)10.31 (0.05-2.05)
    Other116150.62 (0.38-1.00)70.64 (0.30-1.35)0.6210.39 (0.05-2.82)10.38 (0.06-2.45)*
Age, y
    <611,4093521.01401.0531.0371.0
    ≥611,4213200.94 (0.82-1.08)1210.86 (0.68-1.10)0.71340.98 (0.63-1.51)311.06 (0.67-1.68)0.59
BMI, kg/m2
    <259031911.0811.0251.0251.0
    25-29.91,3553081.09 (0.92-1.28)1130.96 (0.73-1.27)381.11 (0.68-1.83380.84 (0.49-1.45)
    ≥306481721.27 (1.06-1.53)651.13 (0.83-1.56)0.59211.64 (0.97-2.79)211.33 (0.75-2.36)0.52
P for trend0.010.480.070.35
Smoking
    Never1,0271631.0951.0221.0231.0
    Former1,2723331.67 (1.41-1.97)1130.98 (0.75-1.28)391.74 (1.02-2.98)321.21 (0.72-2.03)
    Current5111732.18 (1.80-2.65)521.11 (0.80-1.54)0.0001263.42 (1.91-6.11)131.51 (0.80-2.86)0.94
Alcohol
    Nondrinker8561921.0851.0241.0191.0
    Drinker1,8494571.05 (0.90-1.22)1640.88 (0.68-1.14)0.12621.19 (0.73-1.92)481.20 (0.73-1.98)0.94
  • Abbreviation: RR, relative risk.

  • *Results could not be calculated because model did not converge.

  • Relative risk adjusted for age, sex, center, treatment, time since randomization, study number, and smoking status (when not the stratifying variable).