Table 4.

Odds ratios (95% CIs) of invasive breast cancer by estrogen receptor status, premenopausal women, New York University Women's Health Study (145 estrogen receptor–positive cases/145 controls and 52 estrogen receptor–negative cases/52 controls)

CharacteristicQuartile 1Quartile 2Quartile 3Quartile 4Ptrend
2-OHE1, pg/mL
ER+
    Unadjusted*1.00 (reference)2.29 (1.13-4.66)1.66 (0.77-3.57)2.56 (1.11-5.89)0.12
    Adjusted1.00 (reference)2.74 (1.17-6.41)1.91 (0.76-4.76)2.38 (0.84-6.74)0.41
ER-
    Unadjusted*1.00 (reference)0.76 (0.24-2.38)0.85 (0.30-2.40)0.66 (0.14-3.12)0.66
    Adjusted1.00 (reference)1.26 (0.26-6.06)1.02 (0.27-3.91)2.39 (0.25-22.49)0.70
16α-OHE1, pg/mL
ER+
    Unadjusted*1.00 (reference)1.29 (0.68-2.44)1.12 (0.61-2.06)0.83 (0.41-1.70)0.65
    Adjusted1.00 (reference)1.21 (0.59-2.52)0.92 (0.45-1.90)0.59 (0.26-1.34)0.18
ER-
    Unadjusted*1.00 (reference)1.91 (0.61-5.94)1.04 (0.33-3.33)1.15 (0.36-3.71)0.92
    Adjusted1.00 (reference)2.44 (0.50-11.93)1.70 (0.36-7.94)1.38 (0.28-6.78)0.64
2-OHE1:16α-OHE1 ratio
ER+
    Unadjusted*1.00 (reference)1.24 (0.63-2.43)1.83 (0.91-3.66)2.24 (1.07-4.68)0.02
    Adjusted1.00 (reference)1.44 (0.65-3.18)1.79 (0.80-4.00)2.15 (0.88-5.27)0.09
ER-
    Unadjusted*1.00 (reference)1.06 (0.34-3.28)1.13 (0.32-4.00)0.62 (0.14-2.80)0.64
    Adjusted1.00 (reference)1.12 (0.29-4.41)1.69 (0.34-8.40)1.18 (0.21-6.49)0.74

Abbrevaitions: ER+, estrogen receptor positive; ER-, estrogen receptor negative.

  • *Conditional logistic regression (matching variables: age, date of blood donation, day and phase of menstrual cycle).

  • Conditional logistic regression (matching variables: age, date of blood donation, day and phase of menstrual cycle) adjusting for first-degree family history of breast cancer (negative, one affected relative ≥45 years old, one affected relative <45 years old, or more than one affected relative), ever smoking (no, yes), BMI (log2 transformation), age at menarche (log transformed), or parity/age at first full-term pregnancy (<20, 20-24, 25-29, 30+, nulliparous).