Table 2.

Mean (SD) levels of estrogen metabolites by smoking status, family history of breast cancer, and BMI among premenopausal controls, New York University Women's Health Study

Characteristicn2-OHE1, pg/mL16α-OHE1, pg/mL2-OHE1:16α-OHE1 ratio
Age at sampling, y
    <45212273.1 (151.0)376.4 (113.2)0.77 (0.50)
    45-49111268.7 (162.5)355.5 (106.0)0.78 (0.48)
    ≥5054207.8 (139.2)327.4 (85.4)0.65 (0.43)
    Ptrend0.0020.0040.12
Age at menarche, y
    <1292283.1 (169.9)375.8 (121.7)0.81 (0.61)
    12112274.1 (149.3)371.7 (92.3)0.77 (0.45)
    1388255.3 (168.4)341.9 (100.6)0.75 (0.41)
    >1381232.7 (120.8)356.8 (120.4)0.71 (0.47)
    Ptrend*0.020.050.20
Full-term pregnancy
    Never134284.5 (162.6)355.8 (89.2)0.83 (0.50)
    Ever243250.3 (148.2)367.3 (118.0)0.72 (0.47)
    P*0.040.080.03
Age at first full term pregnancy, y
    <2027251.0 (184.0)346.9 (107.7)0.74 (0.53)
    20-24114250.1 (145.0)373.9 (122.2)0.72 (0.52)
    25-2958246.2 (140.1)367.9 (125.9)0.71 (0.43)
    ≥3044256.0 (147.2)361.8 (103.2)0.72 (0.38)
    Ptrend*0.180.430.22
Use of oral contraceptives
    Never127248.8 (142.1)362.6 (116.5)0.73 (0.47)
    Ever207272.8 (155.9)365.0 (106.5)0.79 (0.51)
    P*0.230.960.23
Smoking status
    Never173254.3 (137.3)372.3 (107.5)0.71 (0.45)
    Ever176270.6 (160.7)355.0 (113.5)0.81 (0.53)
    P*0.430.060.06
Family history of breast cancer
    Negative300265.1 (152.9)363.3 (106.0)0.76 (0.46)
    Positive77252.0 (159.6)362.7 (119.2)0.75 (0.58)
    P*0.420.990.57
BMI categories
    Normal (<25.0 kg/m2)262269.0 (155.0)363.0 (109.6)0.78 (0.50)
    Overweight (25.0-29.9 kg/m2)85249.3 (144.5)361.4 (106.9)0.70 (0.37)
    Obese (≥30.0 kg/m2)29238.6 (175.3)370.3 (110.8)0.70 (0.61)
    Ptrend*0.420.470.16
  • *Age adjusted.