Table 2.

Kaplan-Meier estimates of survival among 410 women with epithelial ovarian cancer

Variablen*DeathsSurvival probability (95% CI)
P
5 y10 y15 y
Overall4102120.61 (0.56-0.66)0.52 (0.47-0.57)0.48 (0.43-0.53)
LOC
    Low138580.66 (0.57-0.73)0.62 (0.53-0.69)0.57 (0.48-0.65)
    Medium136640.66 (0.57-0.73)0.56 (0.48-0.64)0.53 (0.44-0.61)0.0001
    High136900.51 (0.42-0.59)0.37 (0.29-0.46)0.33 (0.25-0.42)
Parity
    Nulliparous104490.65 (0.55-0.73)0.58 (0.48-0.67)0.54 (0.44-0.63)
    1-2 births169820.64 (0.56-0.71)0.53 (0.45-0.60)0.51 (0.43-0.58)0.1063
    ≥3 births137810.55 (0.46-0.63)0.46 (0.37-0.54)0.40 (0.31-0.48)
Use of oral contraceptives§
    Yes169710.70 (0.62-0.76)0.61 (0.53-0.68)0.57 (0.49-0.64)0.0012
    No2411410.55 (0.49-0.61)0.46 (0.39-0.52)0.42 (0.35-0.48)
Breast-feeding history (mo)
    Nulliparous104490.65 (0.55-0.73)0.58 (0.48-0.67)0.54 (0.44-0.63)
    Never breast-fed178960.58 (0.50-0.65)0.48 (0.41-0.56)0.45 (0.38-0.52)0.6214
    1-355310.58 (0.44-0.70)0.47 (0.34-0.60)0.43 (0.30-0.56)
    ≥473360.65 (0.53-0.75)0.56 (0.43-0.66)0.50 (0.38-0.61)
Age at menarche (y)
    <1277460.52 (0.40-0.62)0.43 (0.32-0.54)0.41 (0.29-0.51)
    12-132281100.64 (0.57-0.70)0.54 (0.48-0.61)0.51 (0.44-0.57)0.1880
    ≥14105560.63 (0.53-0.71)0.53 (0.43-0.62)0.46 (0.37-0.56)
Menopause status
    Premenopausal2581120.70 (0.64-0.75)0.59 (0.53-0.65)0.56 (0.50-0.62)<0.0001
    Postmenopausal132920.43 (0.34-0.51)0.36 (0.28-0.44)0.30 (0.22-0.38)
Age at first birth (y)
    Nulliparous104490.65 (0.55-0.73)0.58 (0.48-0.67)0.54 (0.44-0.63)
    ≤1973330.65 (0.53-0.75)0.56 (0.44-0.67)0.53 (0.41-0.64)
    20-24147800.60 (0.52-0.68)0.50 (0.41-0.58)0.45 (0.37-0.53)0.1756
    25-2969380.56 (0.44-0.67)0.49 (0.37-0.60)0.44 (0.32-0.56)
    ≥3017120.47 (0.23-0.68)0.28 (0.10-0.51)0.28 (0.10-0.51)
Hysterectomy
    Yes39220.51 (0.35-0.66)0.46 (0.30-0.61)0.44 (0.28-0.58)0.5143
    No3691890.62 (0.57-0.67)0.52 (0.47-0.57)0.48 (0.43-0.53)
Tubal sterilization
    Yes42280.49 (0.33-0.63)0.39 (0.24-0.53)0.31 (0.17-0.45)0.0332
    No3651830.62 (0.57-0.67)0.53 (0.48-0.58)0.50 (0.44-0.55)
Age at diagnosis (y)
    20-40130400.79 (0.71-0.85)0.70 (0.61-0.77)0.68 (0.59-0.75)
    41-50175990.59 (0.51-0.66)0.48 (0.41-0.56)0.43 (0.35-0.50)<0.0001
    51-54105730.44 (0.34-0.53)0.36 (0.27-0.45)0.32 (0.23-0.41)
Stage of disease
    Localized159390.85 (0.78-0.90)0.79 (0.71-0.84)0.75 (0.67-0.81)<0.0001
    Regional/distant2511730.46 (0.40-0.52)0.35 (0.29-0.41)0.31 (0.25-0.37)
Histology
    Serous1931040.59 (0.51-0.65)0.50 (0.42-0.56)0.46 (0.39-0.53)
    Mucinous56130.89 (0.77-0.95)0.83 (0.70-0.91)0.75 (0.60-0.84)0.0002
    Endometriod77500.53 (0.41-0.63)0.39 (0.28-0.50)0.35 (0.24-0.46)
    Other84450.57 (0.46-0.67)0.49 (0.38-0.59)0.46 (0.35-0.57)
  • NOTE: Survival = from any cause of death after ovarian cancer diagnosis, through December 31, 1997; women were participants in the CASH study, 1980 to 1982.

  • * Due to missing data, values may not add to 410.

  • Log-rank test for equality of survivor functions.

  • Age-specific cut points for low, medium, and high LOC (respectively) were as follows: ages 20 to 40: ≤174, 175 to 247, and 248+; ages 41 to 50: ≤377, 378 to 419, and 420+; ages 51 to 54: ≤424, 425 to 451, and 452+.

  • § Yes = ≥3 consecutive mo; no = never used or used <3 consecutive mo.

  • Other includes other epithelial (n = 8), clear cell tumors (n = 35), and tumors for which no review was done by the CASH panel (n = 41).