Table 2.

Summary results of prostate cancer association in AAs

CHRSNPBPAllelesRisk alleleAllele frequency
Association test
CaseContOR (95%CI)P*
A. SNPs implicated in GWAS in populations of European descent
2p15rs72104863,043,382A/GA0.0510.0411.20 (0.86-1.68)0.29
3p12rs266075387,193,364T/CT0.5050.4831.17 (1.02-1.35)0.029
6q25rs9364554160,804,075T/CT0.0640.0640.91 (0.68-1.22)0.52
7p15rs1048656727,749,803T/CC0.7370.7141.15 (0.99-1.34)0.075
7q21rs646565797,460,978T/CC0.8700.8701.10 (0.89-1.36)0.38
8q24 (region 2)rs16901979128,194,098A/CA0.4950.4311.38 (1.19-1.60)1.7E-05
8q24 (region 3)rs6983267128,482,487T/GG0.9100.8991.22 (0.96-1.55)0.10
8q24 (region 1)rs1447295128,554,220A/CA0.3260.3251.06 (0.91-1.23)0.46
9q33rs1571801121,506,927T/GT0.1510.1381.07 (0.88-1.31)0.48
10q11rs1099399451,219,502C/TT0.6200.6041.11 (0.96-1.28)0.15
10q26rs4962416126,686,862G/AG0.1750.1741.04 (0.86-1.24)0.72
11q13 (region 2)rs1241845168,691,995A/GA0.1200.1270.91 (0.74-1.13)0.39
11q13 (region 1)rs1089644968,751,243A/GG0.7050.6901.08 (0.92-1.26)0.35
17q12 (region 2)rs1164974333,149,092T/CC0.9370.9311.13 (0.85-1.49)0.40
17q12 (region 1)rs443079633,172,153T/CT0.3620.3251.16 (1.00-1.34)0.056
17q24.3rs185996266,620,348G/TG0.3330.3181.05 (0.91-1.22)0.50
19q13rs88739146,677,464T/CT0.5030.4951.01 (0.89-1.16)0.84
19q13 (KLK3)rs273583956,056,435A/GG0.6710.6940.86 (0.74-1.00)0.056
22q13rs962311738,776,619T/CC0.7580.7491.09 (0.93-1.29)0.30
Xp11rs594561951,074,708G/AG0.4070.3641.22 (0.99-1.49)0.058
B. SNPs implicated in previous fine mapping studies of 8q24 among AA populations
8q24rs7008482126,336,812T/GG0.8580.8421.25 (1.02-1.54)0.034
8q24rs2124036126,717,316T/CC0.7950.7821.14 (0.95-1.36)0.15
8q24rs780321127,152,877C/TT0.7300.7191.14 (0.97-1.33)0.107
8q24rs16901896128,079,950G/AG0.0730.0571.27 (0.95-1.69)0.10
8q24rs10086908128,081,119C/TT0.7930.7441.31 (1.11-1.55)1.1E-03
8q24rs4871005128,082,558C/AA0.7140.6701.24 (1.06-1.44)6.4E-03
8q24§rs1456310128,121,615G/AG0.3790.3990.91 (0.78-1.04)0.17
8q24rs1016343128,162,479T/CT0.2450.2131.16 (0.99-1.37)0.071
8q24rs6981122128,163,642A/CC0.7220.6901.22 (1.04-1.42)0.013
8q24rs7007694128,168,348C/TT0.7790.7491.15 (0.98-1.35)0.10
8q24rs13254738128,173,525A/CC0.6810.6231.36 (1.17-1.58)4.9E-05
8q24rs6983561128,176,062C/AC0.5110.4571.31 (1.13-1.52)2.8E-04
8q24§rs16901966128,179,434G/AG0.3390.3291.08 (0.93-1.26)0.32
8q24rs7000448128,510,352C/TT0.6920.6521.20 (1.03-1.40)0.016
  • * Association was tested under an additive model and adjusted for age, ancestry proportion and study population.

  • Reported in Robbins et al. (2007).

  • Implicated in a subset of JHH study (372 cases and 350 controls).

  • § Reported in Salinas et al. (2008).

  • Reported in Haiman et al. (2007) and Salinas et al. (2008).