Table 5.

Association of haplotypes in the caspase-7 gene with endometrial cancer risk stratified by menopausal status, the Shanghai Endometrial Cancer Study 1997 to 2003

HaplotypeAge-adjusted OR (95% CI)
DominantAdditiveRecessive
Premenopausal women
    Block 1*
        Hap1: AGTTAGGGGTC1.001.001.00
        Hap2: CGGTAGCGCCC0.81 (0.59-1.11)0.89 (0.66-1.21)1.49 (0.81-2.76)
        Hap3: CGTTAGCAGCC1.20 (0.88-1.64)1.25 (0.92-1.68)1.52 (0.85-2.70)
        Hap4: CATTGGGGGTT0.82 (0.57-1.19)0.78 (0.55-1.12)0.25 (0.03-1.79)
        Hap5: CGGTACCGGCC1.12 (0.77-1.64)1.11 (0.76-1.61)0.91 (0.28-2.97)
        Hap6: CGTGAGGGGCC0.60 (0.40-0.88)0.61 (0.42-0.89)0.65 (0.15-2.71)
    Block 2
        Hap1: ATGGGC1.001.001.00
        Hap2: GTGGGC0.78 (0.57-1.07)0.87 (0.65-1.16)1.29 (0.70-2.36)
        Hap3: AGAGGC1.12 (0.80-1.56)1.16 (0.84-1.61)1.29 (0.58-2.88)
        Hap4: ATGAAC0.96 (0.70-1.30)1.04 (0.77-1.39)1.41 (0.77-2.59)
        Hap5: AGGGGG1.19 (0.76-1.86)1.25 (0.80-1.94)1.50 (0.35-6.39)
        Hap6: ATGAGC0.59 (0.40-0.88)0.62 (0.42-0.91)0.67 (0.16-2.79)
        Hap7: AGGGGC0.76 (0.41-1.40)0.76 (0.41-1.40)
Postmenopausal women
    Block 1*
        Hap1: AGTTAGGGGTC1.001.001.00
        Hap2: CGGTAGCGCCC1.27 (0.99-1.63)1.23 (0.97-1.55)0.95 (0.57-1.58)
        Hap3: CGTTAGCAGCC1.07 (0.82-1.38)1.08 (0.85-1.39)1.05 (0.60-1.83)
        Hap4: CATTGGGGGTT1.20 (0.88-1.64)1.15 (0.85-1.56)0.43 (0.10-1.77)
        Hap5: CGGTACCGGCC1.06 (0.77-1.47)1.15 (0.84-1.57)1.97 (0.88-4.38)
        Hap6: CGTGAGGGGCC0.97 (0.70-1.35)1.00 (0.73-1.38)1.11 (0.40-3.08)
    Block 2
        Hap1: ATGGGC1.001.001.00
        Hap2: GTGGGC1.35 (1.06-1.73)1.34 (1.07-1.68)1.16 (0.73-1.84)
        Hap3: AGAGGC0.95 (0.71-1.27)1.03 (0.78-1.36)1.52 (0.75-3.07)
        Hap4: ATGAAC1.19 (0.92-1.53)1.16 (0.91-1.49)0.84 (0.44-1.57)
        Hap5: AGGGGG1.13 (0.77-1.64)1.16 (0.80-1.68)1.23 (0.29-5.13)
        Hap6: ATGAGC0.93 (0.67-1.28)0.94 (0.69-1.28)0.74 (0.23-2.38)
        Hap7: AGGGGC1.06 (0.66-1.71)1.05 (0.65-1.69)
  • NOTE: P for interaction tests for menopausal status with Hap6 in block 1 was 0.61 and with Hap2 and Hap6 in block 2 were 0.0006 and 0.33, respectively, under the additive model.

  • * In the order rs12415607, rs11196418, rs7922608, rs11593766, rs11196438, rs11196444, rs3124740, rs11196445, rs3127075, rs17090904, and rs12359418.

  • In the order rs6585241, rs10787498, rs12247479, rs1127687, rs17090919, and rs10885497.