Table 4.

Association of haplotypes in the caspase-7 gene with endometrial cancer risk, the Shanghai Endometrial Cancer Study, 1997 to 2003

HaplotypeFrequency in cases (%)Frequency in controls (%)Age-adjusted OR (95% CI)
Dominant modelAdditive modelRecessive model
CASP7
Block 1*
Hap1: AGTTAGGGGTC35.835.61.001.001.00
Hap2: CGGTAGCGCCC17.016.31.04 (0.86-1.26)1.06 (0.88-1.27)1.12 (0.76-1.65)
Hap3: CGTTAGCAGCC16.514.61.10 (0.91-1.34)1.13 (0.93-1.36)1.24 (0.83-1.84)
Hap4: CATTGGGGGTT8.79.01.01 (0.80-1.29)0.97 (0.77-1.22)0.35 (0.11-1.11)
Hap5: CGGTACCGGCC8.78.01.07 (0.84-1.37)1.11 (0.88-1.41)1.47 (0.76-2.85)
Hap6: CGTGAGGGGCC7.19.00.78 (0.61-1.00)0.80 (0.63-1.02)0.90 (0.39-2.07)
Block 2
Hap1: ATGGGC39.440.71.001.001.00
Hap2: GTGGGC18.016.51.08 (0.89-1.31)1.13 (0.94-1.35)1.21 (0.84-1.75)
Hap3: AGAGGC11.010.51.02 (0.82-1.28)1.09 (0.88-1.35)1.44 (0.85-2.45)
Hap4: ATGAAC15.214.21.08 (0.89-1.32)1.11 (0.92-1.33)1.06 (0.69-1.65)
Hap5: AGGGGG5.85.11.15 (0.86-1.53)1.19 (0.90-1.58)1.35 (0.49-3.74)
Hap6: ATGAGC7.29.30.77 (0.60-0.98)0.79 (0.62-1.00)0.71 (0.29-1.75)
Hap7: AGGGGC2.73.10.92 (0.63-1.34)0.92 (0.63-1.33)
  • * In the order rs12415607, rs11196418, rs7922608, rs11593766, rs11196438, rs11196444, rs3124740, rs11196445, rs3127075, rs17090904, and rs12359418.

  • In the order rs6585241, rs10787498, rs12247479, rs1127687, rs17090919, and rs10885497.