Table 3.

Association of genetic variants in caspase-7 gene with endometrial cancer risk by menopausal status, the Shanghai Endometrial Cancer Study, 1997 to 2003

GenotypesCases (%)Controls (%)PAge-adjusted OR (95% CI)OR per alleleP for trend
Premenopausal women
    rs11196418
        GG362 (81.5)300 (77.9)0.101.00
        AG80 (18.0)78 (20.3)0.86 (0.61-1.22)
        AA2 (0.5)7 (1.8)0.24 (0.05-1.17)0.78 (0.57-1.07)0.12
        GA/AA82 (18.5)85 (22.1)0.200.81 (0.58-1.14)
    rs11593766
        TT387 (87.4)308 (80.0)0.021.00
        GT54 (12.2)75 (19.5)0.56 (0.38-0.82)
        GG2 (0.5)2 (0.5)0.94 (0.13-6.74)0.60 (0.42-0.86)<0.01
        GT/GG56 (12.6)77 (20.0)<0.010.57 (0.39-0.83)
    rs3124740
        GG151 (34.0)137 (35.5)0.081.00
        CG206 (46.4)196 (50.8)0.96 (0.71-1.30)
        CC87 (19.6)53 (13.7)1.51 (1.00-2.29)1.17 (0.96-1.43)0.12
        CG/CC293 (66.0)249 (64.5)0.651.08 (0.81-1.44)
    rs11196445
        GG295 (67.2)286 (74.5)0.021.00
        AG126 (28.7)92 (24.0)1.29 (0.94-1.77)
        AA18 (4.1)6 (1.6)2.95 (1.15-7.56)1.41 (1.08-1.85)0.01
        AG/AA144 (32.8)98 (25.5)0.021.39 (1.03-1.89)
    rs10787498
        TT280 (63.1)255 (66.2)0.231.00
        GT143 (32.2)120 (31.2)1.09 (0.81-1.47)
        GG21 (4.7)10 (2.6)1.94 (0.89-4.22)1.19 (0.93-1.53)0.17
        TG/GG164 (36.9)130 (33.8)0.341.15 (0.87-1.54)
Postmenopausal women
    rs11196418
        GG463 (79.3)501 (81.3)0.211.00
        GA117 (20.0)106 (17.2)1.20 (0.90-1.61)
        AA4 (0.7)9 (1.5)0.48 (0.15-1.57)1.08 (0.83-1.40)0.59
        GA/AA121 (20.7)115 (18.7)0.371.14 (0.86-1.52)
    rs11593766
        TT496 (85.2)516 (83.8)0.721.00
        GT82 (14.1)94 (15.3)0.91 (0.66-1.26)
        GG4 (0.7)6 (1.0)0.69 (0.19-2.46)0.89 (0.67-1.20)0.45
        GT/GG86 (14.8)100 (16.2)0.490.90 (0.66-1.23)
    rs3124740
        GG175 (30.0)205 (33.3)0.231.00
        CG280 (48.0)298 (48.4)1.10 (0.85-1.43)
        CC128 (22.0)113 (18.3)1.33 (0.96-1.83)1.15 (0.98-1.35)0.09
        CG/CC408 (70.0)411 (66.7)0.231.16 (0.91-1.49)
    rs11196445
        GG407 (70.3)432 (70.4)0.861.00
        AG156 (26.9)168 (27.4)0.99 (0.76-1.28)
        AA16 (2.8)14 (2.3)1.21 (0.58-2.52)1.02 (0.82-1.27)0.85
        AG/AA172 (29.7)182 (29.6)0.981.00 (0.78-1.29)
    rs10787498
        TT395 (67.6)398 (64.5)0.021.00
        TG161 (27.6)204 (33.1)0.80 (0.62-1.02)
        GG28 (4.8)15 (2.4)1.88 (0.99-3.58)0.98 (0.80-1.20)0.81
        TG/GG189 (32.4)219 (35.5)0.250.87 (0.69-1.11)
  • NOTE: P for interaction test for menopausal status with rs11196418, rs11593766, rs3124740, rs11196445, and rs10787498 were 0.26, 0.16, 0.54, 0.16, and 0.28, respectively.