Table 2.

Association of genetic variants in caspase-3, caspase-7, and caspase-8 genes with endometrial cancer risk, the Shanghai Endometrial Cancer Study, 1997 to 2003

GeneSNPAllelesGene regionCase/controls (1,028/1,003)
OR (95% CI)*OR (95% CI)OR (95% CI)P§
CASP3rs4647693G/AIntron1.01 (0.83-1.22)1.04 (0.64-1.69)1.01 (0.86-1.19)0.88
rs2705901C/GBoundary0.91 (0.73-1.12)2.25 (1.03-4.95)1.02 (0.84-1.23)0.86
rs2720378G/CIntron1.10 (0.92-1.33)0.92 (0.68-1.25)1.01 (0.89-1.16)0.86
rs2705881A/GPromoter1.06 (0.89-1.28)0.85 (0.61-1.18)0.98 (0.86-1.12)0.77
CASP7rs12415607C/APromoter0.88 (0.73-1.07)0.98 (0.75-1.28)0.97 (0.85-1.10)0.59
rs11196418G/APromoter1.04 (0.83-1.30)0.36 (0.14-0.94)0.94 (0.76-1.14)0.51
rs7922608T/GIntron0.99 (0.82-1.18)1.33 (0.92-1.93)1.07 (0.93-1.23)0.37
rs11593766T/GNon-synonymous0.75 (0.59-0.96)0.70 (0.24-2.03)0.76 (0.61-0.96)0.02
rs11196438A/GIntron1.02 (0.81-1.27)0.39 (0.15-1.01)0.93 (0.76-1.13)0.46
rs11196444G/CIntron0.99 (0.78-1.26)2.45 (0.77-7.84)1.06 (0.85-1.33)0.59
rs3124740G/CIntron1.03 (0.85-1.26)1.36 (1.06-1.75)1.15 (1.01-1.30)0.03
rs11196445G/AIntron1.11 (0.91-1.35)1.74 (0.99-3.05)1.17 (0.99-1.39)0.06
rs3127075G/CIntron1.01 (0.83-1.22)1.20 (0.72-1.99)1.04 (0.88-1.22)0.68
rs17090904C/TIntron0.82 (0.67-1.01)0.97 (0.76-1.23)0.98 (0.86-1.10)0.68
rs12359418C/TIntron1.01 (0.80-1.26)0.39 (0.12-1.25)0.94 (0.76-1.16)0.57
rs12416109A/GIntron1.06 (0.87-1.29)1.14 (0.90-1.44)1.07 (0.95-1.20)0.27
rs6585241A/GIntron1.09 (0.90-1.32)1.33 (0.81-2.20)1.11 (0.95-1.30)0.20
rs10787498T/G3UTR0.91 (0.75-1.10)1.90 (1.16-3.11)1.06 (0.91-1.24)0.47
rs12247479G/A3UTR0.97 (0.78-1.21)2.23 (0.91-5.46)1.06 (0.87-1.29)0.59
rs1127687G/A3UTR1.00 (0.83-1.21)0.77 (0.53-1.13)0.94 (0.81-1.09)0.40
rs17090919G/A3UTR1.10 (0.90-1.34)1.04 (0.58-1.87)1.07 (0.90-1.28)0.42
rs10885497C/G3UTR1.14 (0.86-1.52)1.98 (0.36-10.81)1.17 (0.89-1.53)0.27
CASP8rs6747918G/APromoter1.03 (0.85-1.24)1.16 (0.80-1.69)1.05 (0.91-1.22)0.49
rs12620010T/GIntron1.02 (0.84-1.23)1.29 (0.88-1.88)1.07 (0.93-1.24)0.34
rs3769827T/C3UTR1.02 (0.85-1.23)1.21 (0.83-1.75)1.06 (0.92-1.22)0.43
rs3769826T/G3UTR0.98 (0.82-1.19)1.14 (0.80-1.64)1.03 (0.89-1.18)0.71
rs7608692G/A5UTR1.07 (0.89-1.29)0.99 (0.73-1.35)1.02 (0.70-1.17)0.73
rs3769825T/C5UTR1.01 (0.83-1.22)1.15 (0.77-1.71)1.04 (0.89-1.20)0.63
rs3754935T/G5UTR1.07 (0.89-1.29)1.30 (0.90-1.86)1.10 (0.96-1.27)0.17
rs10931934C/T5UTR1.09 (0.87-1.36)1.11 (0.87-1.42)1.05 (0.93-1.19)0.42
rs3769823C/T5UTR1.03 (0.86-1.24)0.81 (0.58-1.14)0.96 (0.84-1.10)0.55
rs1861270C/TIntron1.02 (0.85-1.22)0.77 (0.55-1.08)0.94 (0.82-1.08)0.38
rs3754934G/T3UTR1.02 (0.85-1.23)1.22 (0.83-1.79)1.06 (0.92-1.22)0.44
rs1045487G/ASynonymous1.02 (0.85-1.23)0.99 (0.67-1.48)1.01 (0.87-1.17)0.90
rs700636A/CFlanking0.99 (0.80-1.22)1.01 (0.79-1.29)1.00 (0.89-1.14)0.96
  • Abbreviations: AA, major allele homozygotes; BB, minor allele homozygotes, AB, heterozygotes; FR, flanking region; CASP, caspase; SNP, single-nucleotide polymorphism; OR, odds ratio.

  • * AA reference group; estimates for AB genotype, adjusted for age.

  • AA reference group; estimates for BB genotype, adjusted for age.

  • Age-adjusted odds ratio for per allele.

  • § P value for trend test from additive models of effect.