Table 3.

Age-sex-ethnicity adjusted odds ratio (95% CI) for meat intake, doneness preference, pack-years of smoking, and heterocyclic amine intake on colorectal cancer risk by NAT1*10 or NAT2 genotype

Meat intake or pref.Acetylator genotype
Cases/controlsNAT2 slow/intermediateCases/controlsNAT2 rapidCases/controlsNAT1 no*10Cases/controlsNAT1 *10
Red meat (g/1,000 kcal/d)
    0 to <12.8244/367183/1310.89 (0.64-1.24)120/1791162/2580.98 (0.72-1.34)
    12.8 to <22.5260/3931.01 (0.80-1.27)72/1051.01 (0.71-1.44)122/1811.03 (0.74-1.43)152/2760.88 (0.64-1.21)
    22.5 to <102.7246/3891.00 (0.79-1.27)87/1081.20 (0.85-1.69)120/1671.16 (0.83-1.63)168/2840.99 (0.72-1.35)
    P interaction*0.440.77
Processed meat (g/1,000kcal/d)
    0 to <4.7228/388166/1070.99 (0.69-1.42)116/1841139/2620.86 (0.63-1.19)
    4.7 to <9.4270/3721.22 (0.97-1.54)79/1271.00 (0.71-1.40)121/1741.08 (0.77-1.51)169/2741.01 (0.74-1.39)
    9.4 to <88.3252/3891.14 (0.91-1.45)97/1101.48 (1.06-2.07)125/1691.19 (0.86-1.67)174/2821.06 (0.77-1.45)
    P interaction0.130.93
Meat and fat pattern (factor score)
    Tertile 1235/372164/1260.73 (0.51-1.04)106/1791149/2521.04 (0.76-1.44)
    Tertile 2251/3881.03 (0.82-1.30)79/1121.04 (0.74-1.48)123/1761.21 (0.86-1.69)161/2791.03 (0.75-1.42)
    Tertile 3264/3891.14 (0.90-1.45)99/1061.50 (1.08-2.10)133/1721.43 (1.01-2.01)172/2871.15 (0.83-1.58)
    P interaction0.0470.48
Doneness pref.
    Rare/medium373/5631127/1940.95 (0.72-1.25)205/2631238/4110.77 (0.60-1.00)
    Well done371/5770.99 (0.82-1.21)114/1491.11 (0.83-1.48)156/2600.77 (0.58-1.02)242/4000.81 (0.62-1.06)
    P interaction0.420.09
Pack-years
    0278/475182/1870.70 (0.51-0.96)119/2231183/3600.98 (0.73-1.32)
    >0 to <30336/5201.14 (0.93-1.42)113/1201.61 (1.18-2.20)165/2321.39 (1.02-1.89)223/3501.30 (0.97-1.75)
    ≥30136/1541.48 (1.11-1.97)47/372.02 (1.26-3.24)78/721.98 (1.33-2.96)76/1081.33 (0.91-1.96)
    P interaction0.0030.34
Total HCA (ng/1,000 kcal/d)
    0 to <217.399/363128/1110.82 (0.50-1.34)57/202154/2280.89 (0.58-1.39)
    217.3 to <566.9108/3541.19 (0.87-1.64)35/1141.01 (0.63-1.62)52/1631.15 (0.75-1.79)74/2651.11 (0.73-1.68)
    566.9+96/3741.13 (0.81-1.57)24/1000.88 (0.52-1.48)45/1391.36 (0.86-2.15)53/2810.82 (0.53-1.27)
    P interaction0.970.29
DiMeIQx (ng/1,000 kcal/d)
    0 to <1.893/374122/1000.80 (0.47-1.38)55/192146/2370.74 (0.47-1.16)
    1.8 to <6.2105/3411.32 (0.96-1.83)40/1281.13 (0.72-1.78)48/1621.04 (0.67-1.63)76/2591.13 (0.74-1.72)
    6.2+105/3761.29 (0.93-1.79)25/970.97 (0.58-1.64)51/1501.35 (0.86-2.12)59/2780.88 (0.57-1.36)
    P interaction0.930.22
MeIQx (ng/1,000 kcal/d)
    0 to <29.896/356128/1170.78 (0.48-1.29)54/198149/2290.84 (0.54-1.33)
    29.8 to <93.5102/3671.07 (0.77-1.47)35/1021.08 (0.67-1.74)60/1611.35 (0.88-2.08)67/2601.01 (0.66-1.55)
    93.5+105/3681.22 (0.88-1.70)24/1060.83 (0.49-1.40)40/1451.18 (0.73-1.91)65/2851.01 (0.66-1.54)
P interaction0.4970.89
PhIP (ng/1,000 kcal/d)
    0 to <171.1102/367128/1060.83 (0.50-1.36)58/204156/2280.94 (0.61-1.46)
    171.1 to <460.5106/3521.13 (0.83-1.55)35/1190.94 (0.59-1.50)51/1651.13 (0.73-1.76)71/2631.05 (0.70-1.60)
    460.5+95/3721.11 (0.80-1.53)24/1000.87 (0.51-1.46)45/1351.41 (0.89-2.23)54/2830.83 (0.54-1.29)
    P interaction0.980.25
  • * P For interaction was based on the likelihood ratio test (degrees of freedom, 2) comparing a main effects only model and a model including interaction between genotype and exposure represented as two indicator variables.