Table 2.

Summary ORs for SMAD7 and CRAC1 SNPs in breast cancer and colorectal cancer association studies

Locus/SNPStudyGenotypeAllelic OR (95% CI)P trendP heterogeneity
rs4939827BBCT/C1.00 (0.94-1.06)
18q21CGEMS*1.01 (0.90-1.14)
BBC and CGEMS pooled1.00 (0.95-1.06)0.940.88
Colorectal pooled (10)0.85 (0.81-0.89)1 × 10−12
rs12953717BBCC/T1.01 (0.94-1.07)
18q21CGEMS*1.02 (0.91-1.15)
BBC and CGEMS pooled1.01 (0.95-1.07)0.770.83
Colorectal pooled (10)1.17 (1.12-1.22)9.1 × 10−12
rs4464148BBCT/C0.99 (0.93-1.06)
18q21CGEMS*1.03 (0.90-1.17)
BBC and CGEMS pooled1.00 (0.94-1.06)0.950.60
Colorectal pooled (10)1.15 (1.09-1.21)6.68 × 10−8
rs4779584BBCT/C1.00 (0.92-1.08)
15q13CGEMS*1.04 (0.89-1.21)
BBC and CGEMS pooled1.01 (0.94-1.08)0.820.66
Colorectal pooled (11)1.26 (1.19-1.34)4.44 × 10−14
rs10318BBCC/T1.01 (0.94-1.10)
15q13CGEMS*0.99 (0.85-1.15)
BBC and CGEMS pooled1.01 (0.94-1.08)0.800.78
Colorectal pooled (11)1.19 (1.12-1.26)7.93 × 10−9