Table 1.

MMP-3, MMP-1, and MMP-7 SNPs and endometrial cancer risk, evaluated among 1,037 cases and 1,018 controls, the SECS

Gene, SNPRegionAlleles*MAFHWEEndometrial cancer risk, OR (95% CI)
P§ABBBP
MMP-3
    rs645419PromoterG/A32.6%0.5731.1 (0.9-1.3)1.0 (0.8-1.4)0.628
    rs632478PromoterC/A33.0%0.7661.1 (0.9-1.3)1.0 (0.8-1.4)0.717
    rs522616PromoterA/G36.2%0.7001.0 (0.8-1.2)1.2 (0.9-1.6)0.321
    rs679620Exon 2G/A32.9%0.7541.1 (0.9-1.3)1.0 (0.8-1.4)0.765
    rs650108Intron 8A/G40.2%0.9051.0 (0.9-1.3)1.1 (0.8-1.4)0.624
    rs655403Intron 8C/T7.2%0.5521.0 (0.8-1.3)1.5 (0.4-5.3)0.832
MMP-1
    rs484915PromoterA/T34.2%0.3111.0 (0.8-1.2)0.9 (0.7-1.3)0.777
    rs1155764PromoterT/G22.0%0.7650.9 (0.7-1.0)1.1 (0.7-1.7)0.397
    rs509332PromoterA/G13.4%0.1241.1 (0.9-1.4)0.8 (0.4-1.5)0.639
    rs470206PromoterG/A13.4%0.1141.1 (0.9-1.4)0.8 (0.5-1.5)0.672
    rs2075847PromoterT/C24.0%0.2531.1 (0.9-1.3)1.2 (0.8-1.6)0.369
    rs498186PromoterA/C44.0%0.9661.0 (0.8-1.2)0.9 (0.7-1.2)0.507
    rs475007PromoterT/A34.0%0.7020.9 (0.8-1.1)1.1 (0.9-1.5)0.626
    rs996999Intron 4C/T49.1%0.2911.1 (0.9-1.3)1.0 (0.7-1.2)0.731
    rs470558Exon 5G/A12.4%0.6420.9 (0.7-1.1)1.0 (0.5-2.2)0.421
    rs7125062Intron 6C/T30.6%0.4781.0 (0.8-1.2)0.8 (0.6-1.1)0.472
    rs1938901Intron 8T/C42.4%0.6911.1 (0.9-1.3)1.1 (0.9-1.4)0.440
    rs2071231Intron 9T/G20.4%0.6071.1 (0.9-1.3)1.2 (0.8-1.8)0.173
    rs79451893′ FRC/T8.8%0.2500.9 (0.7-1.1)1.3 (0.4-4.3)0.411
    rs14705043′ FRG/A13.9%0.6630.9 (0.7-1.1)0.9 (0.4-1.7)0.328
MMP-7
    rs880197PromoterA/T38.7%0.7550.9 (0.7-1.1)0.9 (0.7-1.1)0.230
    rs17098318PromoterG/A7.9%0.3091.0 (0.8-1.2)2.2 (0.7-7.2)0.782
    rs11568818PromoterA/G8.0%0.2811.0 (0.7-1.2)2.0 (0.6-6.5)0.970
    rs11225307Intron 3A/G26.5%0.4611.1 (0.9-1.3)1.1 (0.8-1.6)0.325
    rs17352054Intron 5A/C12.0%0.6821.2 (1.0-1.5)1.1 (0.6-2.3)0.112
    rs4950413′ FRC/T49.5%0.5080.9 (0.8-1.2)1.0 (0.8-1.2)0.741
    rs108953043′ FRA/G24.5%0.8531.0 (0.8-1.2)1.0 (0.7-1.5)0.865
    rs79353783′ FRT/C23.0%0.9410.9 (0.8-1.1)1.1 (0.7-1.6)0.655
    rs121844133′ FRC/T29.5%0.5770.9 (0.8-1.1)1.0 (0.7-1.4)0.636
    rs112252973′ FRA/T20.7%0.6291.0 (0.8-1.2)0.9 (0.5-1.4)0.572
  • Abbreviations: OR, odds ratio; CI, confidence interval.

  • * Major and minor alleles as determined by the distribution among SECS controls.

  • Minor Allele Frequency (MAF) among SECS controls.

  • Odds ratio and 95% confidence interval for the risk of endometrial cancer, age and education adjusted; AA, major allele homozygous; BB, minor allele homozygous, AB heterozygous; P value for trend.

  • § Hardy-Weinberg equilibrium test, P value among SECS controls.

  • 3′ Flanking region, downstream of the coding region.