Table 3.

Risk of glioma, glioblastoma multiforme, and meningioma with cumulative exposure to lead by genotype for SNPs in genes related to oxidative stress in the National Cancer Institute Adult Brain Tumor Study

Continuous cumulative lead (OR/100 μg/m3 y)
GenersGliomaGlioblastoma multiforme*
Meningioma
Homozygous wild-type
Heterozygous/homozygous variant
PinteractionHomozygous wild-type
Heterozygous/homozygous variant
PinteractionHomozygous wild-type
Heterozygous/homozygous variant
Pinteraction
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)
CATrs7692141.1 (0.9-1.2)0.9 (0.8-1.0)0.11.1 (1.0-1.3)1.0 (0.9-1.1)0.11.3 (1.1-1.6)1.0 (0.9-1.1)0.003
CATrs10011790.9 (0.8-1.0)1.0 (0.9-1.2)0.31.0 (0.9-1.1)1.1 (1.0-1.3)0.051.1 (1.0-1.1)1.2 (1.0-1.4)0.4
GPX1rs10504500.9 (0.8-1.0)1.1 (1.0-1.3)0.0070.9 (0.8-1.1)1.3 (1.1-1.5)0.00040.9 (0.7-1.2)1.4 (1.1-1.8)0.0002
LPOrs81784071.0 (0.9-1.2)1.0 (0.9-1.1)0.71.1 (0.9-1.2)1.0 (0.9-1.1)0.40.04 (0.0004-3.5)1.1 (1.0-1.1)0.002
MPOrs44011021.1 (0.9-1.2)0.9 (0.8-1.1)0.21.1 (0.9-1.3)0.9 (0.8-1.1)0.090.4 (0.1-1.6)1.1 (1.0-1.1)0.02
NCF2rs115886541.0 (0.9-1.2)1.0 (0.9-1.1)0.71.0 (0.8-1.2)1.0 (0.9-1.1)0.81.3 (1.0-1.6)1.0 (0.9-1.1)0.03
NCF4rs20759381.0 (0.8-1.1)1.0 (0.9-1.1)0.71.0 (0.8-1.2)1.0 (0.9-1.1)0.91.2 (1.0-1.3)0.9 (0.6-1.4)0.02
NCF4rs57563811.0 (0.8-1.1)1.0 (0.9-1.1)0.81.0 (0.9-1.2)1.0 (0.9-1.1)0.81.2 (1.0-1.3)0.9 (0.6-1.4)0.02
NCF4rs81376021.0 (0.9-1.1)0.9 (0.8-1.1)0.41.0 (0.9-1.2)0.9 (0.7-1.2)0.41.1 (1.0-1.3)0.4 (0.03-4.7)0.02
NOS1rs4835891.0 (0.9-1.1)1.0 (0.9-1.1)0.61.0 (0.8-1.1)1.1 (0.9-1.3)0.30.6 (0.2-1.5)1.2 (1.0-1.3)0.003
NOS1rs5456540.7 (0.5-1.1)1.0 (0.9-1.1)0.090.5 (0.2-1.2)1.0 (0.9-1.1)0.021.0 (0.8-1.4)1.1 (1.0-1.1)0.9
NOS1rs8162930.9 (0.8-1.1)1.0 (0.9-1.2)0.21.0 (0.8-1.1)1.1 (0.9-1.3)0.20.9 (0.7-1.2)1.2 (1.0-1.3)0.02
NOS1rs11234251.1 (0.9-1.2)0.9 (0.8-1.1)0.11.1 (0.9-1.3)1.0 (0.8-1.1)0.21.2 (1.0-1.4)1.0 (0.9-1.1)0.05
NOS1rs13539391.0 (0.9-1.2)0.9 (0.8-1.1)0.21.1 (0.9-1.2)1.0 (0.8-1.1)0.31.1 (1.0-1.3)1.0 (0.8-1.2)0.04
NOS1rs22919081.0 (0.9-1.2)1.0 (0.9-1.1)0.41.1 (0.9-1.3)1.0 (0.9-1.1)0.31.1 (1.0-1.3)1.0 (0.9-1.1)0.05
NOS1rs47675351.0 (0.8-1.2)1.0 (0.9-1.1)0.91.0 (0.8-1.3)1.0 (0.9-1.1)0.91.2 (1.0-1.5)1.0 (0.9-1.1)0.05
NOS1rs64901211.0 (0.8-1.1)1.0 (0.9-1.1)0.91.0 (0.9-1.2)1.0 (0.9-1.1)0.60.6 (0.2-1.5)1.1 (1.0-1.1)0.05
NOS1rs72989031.0 (0.9-1.1)0.7 (0.5-1.1)0.051.0 (0.9-1.1)0.8 (0.6-1.2)0.31.1 (1.0-1.1)1.1 (0.9-1.4)0.5
NOS2Ars9447251.1 (0.9-1.3)1.0 (0.9-1.1)0.21.1 (0.9-1.4)1.0 (0.9-1.1)0.21.3 (1.0-1.6)1.0 (0.9-1.1)0.03
NOS2Ars47950671.1 (0.9-1.2)1.0 (0.9-1.1)0.31.1 (1.0-1.3)0.9 (0.8-1.1)0.051.2 (1.0-1.6)1.0 (0.9-1.1)0.02
NOS2Ars22975160.9 (0.7-1.1)1.1 (0.9-1.2)0.050.9 (0.8-1.1)1.1 (0.9-1.3)0.21.0 (0.9-1.1)1.1 (0.9-1.2)0.7
NOS2Ars27792521.0 (0.9-1.1)0.9 (0.8-1.1)0.51.0 (0.9-1.2)1.0 (0.8-1.1)0.71.1 (1.0-1.3)0.2 (0.001-36.1)0.03
NOS2Ars80721991.0 (0.8-1.2)1.0 (0.9-1.1)0.91.0 (0.8-1.2)1.0 (0.9-1.1)0.90.1 (0.005-3.7)1.1 (1.0-1.1)0.03
NOS3rs17999830.9 (0.7-1.1)1.0 (0.9-1.1)0.10.9 (0.7-1.1)1.1 (1.0-1.2)0.041.1 (1.0-1.2)1.1 (1.0-1.2)0.4
NOS3rs44968771.0 (0.8-1.3)1.0 (0.9-1.1)0.61.2 (0.9-1.5)1.0 (0.9-1.1)0.11.3 (1.0-1.8)1.0 (1.0-1.1)0.02
NOS3rs127031070.8 (0.7-1.0)1.0 (0.9-1.1)0.040.7 (0.6-1.0)1.0 (0.9-1.1)0.0071.1 (0.9-1.2)1.0 (0.9-1.1)0.6
RAC1rs8365541.0 (0.9-1.1)1.0 (0.9-1.1)0.71.1 (0.9-1.2)1.0 (0.8-1.1)0.31.2 (1.0-1.4)0.9 (0.7-1.2)0.01
RAC1rs64635541.0 (0.9-1.1)1.0 (0.9-1.1)0.81.0 (0.9-1.2)1.0 (0.8-1.1)0.51.2 (1.0-1.3)0.9 (0.6-1.3)0.01
RAC1rs37297901.0 (0.9-1.1)0.9 (0.7-1.1)0.21.0 (0.9-1.1)0.8 (0.6-1.1)0.21.0 (0.9-1.1)1.2 (1.0-1.5)0.04
RAC2rs65721.0 (0.9-1.2)1.0 (0.9-1.1)0.71.1 (0.9-1.3)1.0 (0.9-1.1)0.31.2 (1.0-1.3)1.0 (0.9-1.1)0.04
RAC2rs14760021.0 (0.9-1.1)1.0 (0.9-1.1)0.61.0 (0.9-1.2)1.0 (0.9-1.1)0.61.2 (1.0-1.3)0.9 (0.7-1.3)0.02
RAC2rs22397741.1 (1.0-1.2)0.6 (0.4-0.9)0.00061.1 (1.0-1.3)0.3 (0.08-1.2)0.00021.1 (1.0-1.3)1.0 (0.9-1.1)0.1
RAC2rs22397751.0 (0.9-1.1)1.0 (0.9-1.1)0.81.0 (0.8-1.1)1.0 (0.9-1.1)0.71.2 (1.0-1.4)0.8 (0.4-1.5)0.005
RAC2rs48202741.0 (0.9-1.1)0.8 (0.6-1.1)0.21.0 (0.9-1.1)0.2 (0.02-1.1)0.0021.1 (1.0-1.1)1.3 (0.9-2.0)0.3
RAC2rs48216091.0 (0.8-1.1)1.0 (0.9-1.1)0.81.0 (0.8-1.2)1.0 (0.9-1.1)0.91.2 (1.0-1.3)0.9 (0.7-1.3)0.02
RAC2rs96074321.0 (0.9-1.1)0.6 (0.4-1.0)0.041.0 (0.9-1.1)0.2 (0.03-1.3)0.0051.1 (1.0-1.1)1.3 (0.9-2.0)0.3
SOD1rs2024450.9 (0.8-1.1)1.1 (0.9-1.3)0.10.9 (0.8-1.1)1.2 (1.0-1.4)0.031.0 (0.9-1.1)1.2 (1.0-1.5)0.2
SOD2rs48800.9 (0.8-1.1)1.0 (0.9-1.1)0.10.8 (0.6-1.1)1.1 (1.0-1.2)0.021.1 (1.0-1.2)1.1 (0.9-1.3)0.7
SOD2rs57461361.0 (0.9-1.1)0.9 (0.8-1.1)0.41.0 (0.9-1.1)0.9 (0.8-1.1)0.30.9 (0.5-1.4)1.2 (1.0-1.3)0.02
SOD2rs57461511.0 (0.9-1.1)1.3 (0.7-2.3)0.41.0 (0.9-1.1)0.9 (0.4-1.9)0.81.0 (0.9-1.1)1.7 (0.8-3.5)0.02
SOD3rs6994730.9 (0.8-1.1)1.0 (0.9-1.1)0.11.0 (0.9-1.1)1.1 (1.0-1.2)0.10.8 (0.4-1.3)1.2 (1.1-1.3)0.003
XDHrs75749201.0 (0.8-1.2)1.0 (0.9-1.1)0.91.0 (0.8-1.3)1.0 (0.9-1.1)0.81.3 (1.0-1.6)0.8 (0.6-1.2)0.001
XDHrs14293761.0 (0.9-1.2)1.0 (0.9-1.1)0.41.1 (1.0-1.3)0.9 (0.8-1.1)0.061.2 (1.0-1.4)0.9 (0.6-1.3)0.005
XDHrs170384121.0 (0.9-1.1)1.0 (0.8-1.2)0.71.0 (0.9-1.1)1.2 (0.9-1.5)0.11.1 (1.0-1.1)0.3 (0.05-1.8)0.03
XDHrs67186061.0 (0.9-1.1)1.0 (0.9-1.1)0.51.0 (0.9-1.2)1.0 (0.8-1.1)0.41.1 (1.0-1.3)1.0 (0.8-1.2)0.04
  • NOTE: See Table 2 for genotype frequencies and associations with brain tumor types.

  • * Cases with glioblastoma multiforme are a subset of the cases with glioma.

  • GPX1 rs1050450 is highly correlated with rs1800668 (r2 = 0.9); SOD3 rs699473 is highly correlated with rs2284659 (r2 = 0.9).

  • P ≤ 0.05 after adjustment for multiple comparisons.