Table 2.

Risk of glioma, glioblastoma multiforme, and meningioma with SNPs in genes related to oxidative stress in the National Cancer Institute Adult Brain Tumor Study

GenersGenotypeControls (%)*Glioma
Glioblastoma multiforme
Meningioma
Cases (%)*OR (95% CI)Cases (%)*OR (95% CI)Cases (%)*OR (95% CI)
CATrs769214AA207 (45)152 (47)175 (49)152 (44)1
AG/GG250 (55)172 (53)0.9 (0.7-1.2)79 (51)0.9 (0.6-1.3)66 (56)1.1 (0.7-1.7)
CATrs1001179TT249 (57)186 (58)185 (57)172 (61)1
TC/CC186 (42)132 (42)1.0 (0.7-1.3)65 (43)1.0 (0.7-1.5)46 (39)0.8 (0.5-1.2)
GPX1rs1050450§CC236 (52)158 (48)174 (47)155 (46)1
CT/TT221 (48)169 (52)1.1 (0.8-1.5)83 (53)1.1 (0.8-1.6)66 (55)1.3 (0.8-1.9)
LPOrs8178407AA131 (40)92 (37)143 (37)129 (29)1
AG/GG196 (60)159 (63)1.2 (0.9-1.7)73 (63)1.2 (0.7-1.9)70 (70)1.6 (1.0-2.7)
MPOrs4401102GG183 (56)137 (55)160 (52)155 (55)1
GA/AA144 (44)114 (45)1.0 (0.7-1.4)56 (48)1.2 (0.8-1.9)45 (45)1.0 (0.6-1.7)
NCF2rs11579965GG291 (89)211 (84)1102 (88)179 (79)1
GC/CC37 (11)40 (16)1.5 (0.9-2.5)14 (12)1.1 (0.5-2.3)21 (21)2.0 (1.1-3.9)
NCF2rs11588654AA150 (46)125 (50)152 (45)152 (53)1
AG/GG178 (54)126 (50)0.8 (0.6-1.2)64 (55)1.0 (0.6-1.6)47 (47)0.7 (0.4-1.2)
NCF4rs2075938AA181 (55)143 (57)170 (60)154 (54)1
AG/GG146 (45)108 (43)1.0 (0.7-1.4)46 (40)0.8 (0.5-1.3)46 (46)1.1 (0.7-1.8)
NCF4rs5756381AA185 (56)147 (59)170 (60)155 (55)1
AG/GG143 (44)104 (41)0.9 (0.7-1.3)46 (40)0.8 (0.5-1.3)45 (45)1.1 (0.7-1.8)
NCF4rs8137602CC261 (80)216 (86)1101 (87)187 (87)1
CG/GG67 (20)35 (14)0.6 (0.4-1.0)15 (13)0.5 (0.3-1.0)13 (13)0.6 (0.3-1.2)
NOS1rs483589CC119 (37)96 (38)148 (41)137 (37)1
CT/TT207 (64)155 (62)1.0 (0.7-1.3)68 (59)0.9 (0.6-1.5)63 (63)1.0 (0.6-1.6)
NOS1rs545654GG92 (28)56 (22)129 (25)127 (27)1
GA/AA235 (72)195 (78)1.3 (0.9-2.0)87 (75)1.1 (0.7-1.9)73 (73)1.0 (0.6-1.7)
NOS1rs816293GG109 (33)93 (38)147 (41)140 (40)1
GC/CC218 (67)155 (63)0.9 (0.6-1.2)69 (59)0.9 (0.5-1.4)60 (60)0.7 (0.4-1.1)
NOS1rs816351TT269 (82)219 (87)1104 (90)178 (79)1
TC/CC59 (18)32 (13)0.6 (0.4-1.0)12 (10)0.5 (0.3-1.0)21 (21)1.4 (0.8-2.6)
NOS1rs1123425TT114 (35)76 (30)142 (36)124 (24)1
TC/CC212 (65)175 (70)1.2 (0.8-1.7)74 (64)0.8 (0.5-1.3)76 (76)1.7 (1.0-3.0)
NOS1rs1353939GG206 (63)154 (61)168 (59)161 (61)1
GA/AA121 (37)97 (39)1.1 (0.8-1.5)48 (41)1.2 (0.8-1.9)39 (39)1.2 (0.7-2.0)
NOS1rs2291908AA162 (50)112 (45)149 (42)144 (44)1
AG/GG164 (50)139 (55)1.3 (0.9-1.7)67 (58)1.4 (0.9-2.2)56 (56)1.4 (0.8-2.2)
NOS1rs4767535GG94 (29)65 (26)129 (25)126 (26)1
GA/AA233 (71)186 (74)1.1 (0.8-1.6)87 (75)1.0 (0.6-1.8)74 (74)1.1 (0.6-1.9)
NOS1rs6490121CC147 (45)104 (42)150 (43)141 (41)1
CT/TT181 (55)146 (58)1.1 (0.8-1.6)66 (57)1.1 (0.7-1.7)59 (59)1.2 (0.7-1.9)
NOS1rs7298903AA271 (83)206 (82)197 (84)182 (83)1
AG/GG55 (17)44 (18)1.0 (0.7-1.6)19 (16)0.9 (0.5-1.7)17 (17)1.2 (0.6-2.3)
NOS1rs10850803TT272 (83)198 (79)191 (78)172 (72)1
TC/CC54 (17)52 (21)1.3 (0.9-2.0)25 (22)1.4 (0.8-2.5)28 (28)2.0 (1.1-3.6)
NOS2Ars944725GG117 (36)92 (37)142 (36)140 (40)1
GA/AA211 (64)159 (63)1.0 (0.7-1.4)74 (64)0.8 (0.5-1.3)60 (60)0.7 (0.4-1.2)
NOS2Ars2297516TT119 (37)99 (39)146 (40)137 (37)1
TG/GG207 (64)152 (61)0.9 (0.7-1.3)70 (60)0.9 (0.6-1.4)63 (63)1.0 (0.6-1.6)
NOS2Ars2779252CC298 (91)231 (92)1109 (94)191 (91)1
CA/AA29 (9)20 (8)0.8 (0.5-1.5)7 (6)0.6 (0.3-1.6)9 (9)1.2 (0.5-2.7)
NOS2Ars4795067TT141 (43)104 (41)155 (47)138 (38)1
TC/CC187 (57)147 (59)1.0 (0.7-1.5)61 (53)0.8 (0.5-1.3)62 (62)1.1 (0.7-1.9)
NOS2Ars8072199GG124 (38)79 (31)140 (34)128 (28)1
GA/AA203 (62)172 (69)1.3 (0.9-1.8)76 (66)1.0 (0.6-1.6)71 (72)1.7 (1.0-3.0)
NOS3rs1799983TT203 (44)150 (46)173 (47)152 (43)1
TG/GG261 (56)176 (54)0.9 (0.7-1.2)84 (54)1.0 (0.6-1.4)69 (57)0.9 (0.6-1.4)
NOS3rs4496877GG107 (33)88 (35)135 (30)139 (39)1
GT/TT219 (67)163 (65)0.9 (0.6-1.3)81 (70)1.1 (0.7-1.8)61 (61)0.7 (0.4-1.1)
NOS3rs12703107GG188 (57)136 (54)166 (57)151 (52)1
GT/TT140 (43)115 (46)1.1 (0.8-1.6)50 (43)1.1 (0.7-1.8)48 (48)1.3 (0.8-2.1)
RAC1rs836554CC193 (59)146 (58)168 (59)152 (52)1
CT/TT134 (41)105 (42)1.1 (0.8-1.5)48 (41)0.9 (0.6-1.5)48 (48)1.3 (0.8-2.2)
RAC1rs6463554GG235 (72)198 (79)195 (82)169 (69)1
GC/CC93 (28)53 (21)0.7 (0.5-1.0)21 (18)0.5 (0.3-0.9)31 (31)1.1 (0.7-1.9)
RAC1rs3729790GG193 (59)148 (59)168 (59)164 (64)1
GA/AA135 (41)103 (41)1.0 (0.7-1.5)48 (41)1.1 (0.7-1.8)36 (36)0.7 (0.5-1.2)
RAC2rs6572GG108 (33)80 (32)137 (32)126 (26)1
GC/CC220 (67)171 (68)1.0 (0.7-1.5)79 (68)1.2 (0.7-1.9)74 (74)1.4 (0.8-2.4)
RAC2rs1476002AA248 (76)191 (76)190 (78)168 (68)1
AG/GG79 (24)60 (24)1.0 (0.7-1.4)26 (22)0.8 (0.5-1.4)32 (32)1.6 (0.9-2.7)
RAC2rs2213430AA102 (31)69 (27)130 (26)137 (27)1
AG/GG226 (69)182 (73)1.3 (0.9-1.8)86 (74)1.2 (0.7-2.0)63 (63)0.5 (0.3-0.8)
RAC2rs2239774CC239 (73)186 (74)189 (77)173 (73)1
CG/GG89 (27)65 (26)0.9 (0.6-1.4)27 (23)0.9 (0.6-1.6)27 (27)1.2 (0.7-2.1)
RAC2rs2239775GG240 (73)202 (80)188 (76)166 (66)1
GT/TT87 (27)49 (20)0.6 (0.4-0.9)28 (24)0.8 (0.5-1.3)34 (34)1.8 (1.1-3.1)
RAC2rs4820274GG252 (77)185 (74)187 (75)167 (67)1
GC/CC75 (23)66 (26)1.2 (0.8-1.8)29 (25)1.3 (0.8-2.2)33 (33)1.9 (1.1-3.3)
RAC2rs4821609TT161 (49)132 (53)161 (53)148 (48)1
TC/CC165 (51)119 (47)0.9 (0.6-1.2)55 (47)0.9 (0.6-1.4)52 (52)1.1 (0.6-1.8)
RAC2rs9607432AA267 (82)199 (79)194 (81)175 (75)1
AG/GG60 (18)52 (21)1.2 (0.8-1.8)22 (19)1.3 (0.7-2.4)25 (25)1.9 (1.0-3.4)
SOD1rs202445TT209 (64)165 (65)172 (62)172 (72)1
TC/CC117 (36)86 (34)0.9 (0.6-1.3)44 (38)0.9 (0.6-1.5)28 (28)0.7 (0.4-1.2)
SOD2rs4880TT121 (27)79 (25)137 (24)139 (33)1
TC/CC327 (73)240 (75)1.1 (0.8-1.6)117 (76)1.1 (0.7-1.8)80 (67)0.8 (0.5-1.2)
SOD2rs2758352TT194 (59)156 (62)178 (67)154 (54)1
TC/CC133 (41)94 (38)0.9 (0.6-1.3)38 (33)0.6 (0.4-1.0)46 (46)1.1 (0.7-1.8)
SOD2rs5746136GG163 (50)119 (47)149 (42)144 (44)1
GA/AA164 (50)132 (53)1.1 (0.8-1.5)67 (58)1.4 (0.9-2.3)56 (56)1.4 (0.9-2.2)
SOD2rs5746151GG289 (88)219 (87)1100 (86)183 (83)1
AG/AA39 (12)32 (13)1.1 (0.7-1.8)16 (14)1.6 (0.8-3.2)17 (17)1.9 (0.9-3.9)
SOD3rs699473§CC208 (45)125 (39)166 (42)141 (34)1
CT/TT251 (55)199 (61)1.3 (1.0-1.8)90 (58)1.1 (0.8-1.7)80 (66)1.7 (1.1-2.6)
XDHrs206849TT102 (31)99 (39)149 (42)138 (38)1
TC/CC224 (69)152 (61)0.7 (0.5-1.0)67 (58)0.6 (0.4-1.0)62 (62)0.9 (0.6-1.5)
XDHrs207444TT290 (89)226 (90)1103 (89)196 (96)1
TC/CC37 (11)25 (10)0.9 (0.5-1.6)13 (11)1.0 (0.5-2.0)4 (4)0.3 (0.09-0.8)
XDHrs494852GG235 (72)157 (63)171 (61)162 (62)1
GA/AA92 (28)94 (37)1.5 (1.1-2.2)45 (39)1.6 (1.0-2.7)38 (38)1.4 (0.9-2.4)
XDHrs1429376TT175 (53)133 (53)161 (53)151 (51)1
TG/GG152 (46)118 (47)1.0 (0.7-1.4)55 (47)1.0 (0.6-1.6)49 (49)1.0 (0.6-1.6)
XDHrs7574920CC77 (24)63 (25)121 (18)120 (20)1
CG/GG250 (76)187 (75)0.9 (0.6-1.3)95 (82)1.4 (0.8-2.5)80 (80)1.2 (0.6-2.1)
XDHrs6718606GG221 (67)157 (63)166 (57)166 (66)1
GC/CC107 (33)94 (37)1.3 (0.9-1.8)50 (43)1.8 (1.1-2.8)34 (34)1.0 (0.6-1.7)
XDHrs17038412AA222 (68)174 (69)177 (66)166 (66)1
AT/TT106 (32)77 (31)0.9 (0.6-1.3)39 (34)1.0 (0.6-1.6)34 (34)1.1 (0.6-1.8)
  • * Same group of controls used for each tumor type; final numbers consist of individuals with nonmissing data for cumulative lead exposure that were successfully genotyped.

  • Cases with glioblastoma multiforme are a subset of the cases with glioma.

  • See Table 3 for effect modification results with cumulative lead exposure.

  • § GPX1 rs1050450 is highly correlated with rs1800668 (r2 = 0.9); SOD3 rs699473 is highly correlated with rs2284659 (r2 = 0.9).