Table 3.

Associations between SNPs and risk of NSCLC by smoking history among Caucasians

Single-nucleotide polymorphismNever smokers
Ever Smokers
Cases, nControls, nOR* (95% CI)PCases, nControls, nOR (95% CI)P
rs1494555-IL7R
    AA1890128103
    AG/GG171030.95 (0.45-2.03)0.97198801.97 (1.28-3.03)0.15
rs2857261-IL15
    AA15498563
    AG/GG211450.46 (0.21-1.00)0.462421201.75 (1.10-2.78)0.65
rs1800630-TNF
    CC21151231134
    AC/AA14432.32 (1.06-5.07)0.4697491.19 (0.74-1.91)0.84
rs4871857-TNFRSF10A
    GG14479054
    CG/CC221460.41 (0.19-0.90)0.462361281.38 (0.85-2.23)0.84
rs3024496-IL10
    AA16568950
    AG/GG201370.46 (0.21-0.98)0.462381330.75 (0.46-1.21)0.84
rs3024491-IL10
    CC16568950
    AC/AA201370.46 (0.21-0.98)0.462381330.75 (0.46-1.21)0.84
  • * Adjusted for age at diagnosis/interview, years of education, family history of lung cancer, history of COPD, years since COPD diagnosis, adult aspirin use (never/ever), and BMI.

  • Adjusted for multiple comparisons via the Benjamini and Hochberg false discovery rate method.

  • Adjusted for age at diagnosis/interview, smoking history (pack-year), years of education, family history of lung cancer, history of COPD, years since COPD diagnosis, adult aspirin use (never/ever), and BMI.