Table 3.

Tag-SNPs associated with risk of glioblastoma at Ptrend of <0.01 in pooled hospital-based case-control study of adult glioma conducted by the NCI and population-based case-control study of adult glioma conducted by the NIOSH

Region GeneSNP IDGenotypeNCI
NIOSH
Pooled
Control n (%)Case n (%)OR*, (95% CI)Control n (%)Case n (%)OR§ (95% CI)OR (95% CI)
STAT1/STAT4
    STAT1rs2066804GG166 (50.3)83 (66.4)1.00296 (55.4)78 (61.4)1.001.00
AG142 (43.0)40 (32.0)0.48 (0.30-0.78)210 (39.3)45 (35.4)0.77 (0.51-1.16)0.63 (0.46-0.86)
AA22 (6.7)2 (1.6)0.14 (0.03-0.66)28 (5.2)4 (3.2)0.50 (0.17-1.50)0.30 (0.12-0.72)
Ptrend0.000080.1020.0001
    GLSrs13035504CC245 (74.5)79 (63.2)1.00395 (74.4)84 (65.1)1.001.00
CG81 (24.6)43 (34.4)1.63 (1.00-2.66)123 (23.2)39 (30.2)1.50 (0.96-2.34)1.55 (1.12-2.15)
GG3 (0.9)3 (2.4)1.58 (0.30-8.52)13 (2.5)6 (4.7)2.28 (0.82-6.34)2.05 (0.85-4.97)
Ptrend0.0550.0300.004
DEFB127/126
    DEFB127rs1434789**TT143 (43.3)46 (36.8)1.00215 (40.3)37 (28.9)1.001.00
GT147 (44.6)62 (49.6)1.26 (0.78-2.04)270 (50.6)64 (50.0)1.40 (0.89-2.19)1.34 (0.97-1.86)
GG40 (12.1)17 (13.6)1.44 (0.71-2.94)49 (9.2)27 (21.1)3.91 (1.81-5.98)2.39 (1.51-3.78)
Ptrend0.240.00020.0004
    DEFB126rs6054706**TT105 (31.9)32 (25.6)1.00174 (32.7)31 (24.2)1.001.00
CT165 (50.2)68 (54.4)1.45 (0.86-2.45)269 (50.6)65 (50.8)1.41 (0.88-2.27)1.43 (1.00-2.04)
CC59 (17.9)25 (20.0)1.49 (0.77-2.88)89 (16.7)32 (25.0)2.01 (1.14-3.55)1.79 (1.16-2.76)
Ptrend0.1910.0130.006
rs13036802**TT131 (39.8)41 (32.8)1.00222 (41.8)43 (33.3)1.001.00
CT161 (48.9)66 (52.8)1.40 (0.85-2.28)247 (46.5)65 (50.4)1.40 (0.91-2.16)1.41 (1.02-1.95)
CC37 (11.3)18 (14.4)1.66 (0.81-3.40)62 (11.7)21 (16.3)1.79 (0.96-3.24)1.74 (1.09-2.77)
Ptrend0.1120.0400.009
SERPINI1
    SERPINI1rs10513634††TT232 (70.5)104 (83.2)1.00408 (76.7)108 (84.4)1.001.00
AT87 (26.4)20 (16.0)0.45 (0.26-0.80)120 (22.6)19 (14.8)0.61 (0.36-1.05)0.53 (0.36-0.79)
AA10 (3.0)1 (0.8)0.22 (0.03-1.92)4 (0.8)1 (0.8)0.84 (0.09-7.54)0.38 (0.08-1.78)
Ptrend0.0020.0790.001
rs1552746††TT204 (61.8)91 (72.8)1.00365 (68.6)98 (76.6)1.001.00
CT109 (33.0)33 (26.4)0.71 (0.43-1.16)152 (28.6)28 (21.9)0.68 (0.43-1.09)0.69 (0.49-0.98)
CC17 (5.2)1 (0.8)0.12 (0.02-0.95)15 (2.8)2 (1.6)0.56 (0.12-2.46)0.26 (0.08-0.90)
Ptrend0.0140.0790.003
LY96
    LY96rs16938755TT261 (79.1)87 (69.6)1.00404 (75.8)91 (70.5)1.001.00
CT63 (19.1)33 (26.4)1.51 (0.89-2.56)123 (23.1)34 (26.4)1.35 (0.86-2.12)1.42 (1.00-2.00)
CC6 (1.8)5 (4.0)4.98 (1.32-18.79)6 (1.1)4 (3.1)3.03 (0.81-11.34)3.77 (1.48-9.59)
Ptrend0.0140.0690.003
SELP
    SELPrs2236868‡‡GG86 (26.2)42 (33.6)1.00140 (26.3)47 (36.7)1.001.00
AG159 (48.5)60 (48.0)0.77 (0.46-1.29)259 (48.7)54 (42.2)0.63 (0.40-0.99)0.69 (0.49-0.97)
AA83 (25.3)23 (18.4)0.49 (0.26-0.92)133 (25.0)27 (21.1)0.59 (0.34-1.01)0.54 (0.36-0.82)
Ptrend0.0270.0400.003
rs3917727‡‡AA132 (40.1)65 (52.0)1.00213 (39.8)65 (51.2)1.001.00
AG155 (47.1)48 (38.4)0.68 (0.42-1.08)246 (46.0)49 (38.6)0.63 (0.41-0.96)0.65 (0.48-0.89)
GG42 (12.8)12 (9.6)0.62 (0.29-1.32)76 (14.2)13 (10.2)0.58 (0.30-1.12)0.60 (0.36-0.98)
Ptrend0.0840.0280.005
rs17523783‡‡GG167 (50.8)74 (59.2)1.00259 (48.5)76 (58.9)1.001.00
GT136 (41.3)45 (36.0)0.81 (0.51-1.29)223 (41.8)47 (36.4)0.69 (0.45-1.04)0.74 (0.54-1.01)
TT26 (7.9)6 (4.8)0.53 (0.20-1.41)52 (9.7)6 (4.7)0.43 (0.18-1.05)0.47 (0.24-0.91)
Ptrend0.1520.0280.005
C2
C2rs7746553CC232 (70.3)82 (65.6)1.00377 (70.6)75 (58.6)1.001.00
CG87 (26.4)37 (29.6)1.19 (0.72-1.95)144 (27.0)48 (37.5)1.74 (1.14-2.64)1.48 (1.08-2.04)
GG11 (3.3)6 (4.8)1.72 (0.56-5.29)13 (2.4)5 (3.9)2.15 (0.72-6.43)1.99 (0.90-4.37)
Ptrend0.2920.0060.006
CCL2/CCL7/CCL11/CCL8/CCL13/CCL1
    CCL2rs2857653CC205 (63.1)71 (56.8)1.00357 (67.1)77 (59.7)1.001.00
CT105 (32.3)50 (40.0)1.81 (1.11-2.94)166 (31.2)43 (33.3)1.23 (0.80-0.96)1.46 (1.06-2.00)
TT15 (4.6)4 (3.2)0.72 (0.22-2.38)9 (1.7)9 (7.0)4.90 (1.83-13.13)1.99 (0.95-0.98)
Ptrend0.1690.0150.006
JAK3
    JAK3rs3212741§§D' = 0.65 and r2 = 0.01. All D' and r2 are reported for pooled controls of European background.GG192 (58.2)81 (64.8)1.00319 (59.6)94 (72.9)1.001.00
AG119 (36.1)40 (32.0)0.86 (0.53-1.39)196 (36.6)31 (24.0)0.53 (0.34-0.83)0.66 (0.48-0.92)
AA19 (5.8)4 (3.2)0.51 (0.16-1.66)20 (3.7)4 (3.1)0.67 (0.22-2.05)0.56 (0.25-1.27)
Ptrend0.2510.0090.007
rs2072496§§GG270 (81.8)92 (73.6)1.00438 (82.0)100 (77.5)1.001.00
AG59 (17.9)31 (24.8)1.49 (0.88-2.55)95 (17.8)26 (20.2)1.22 (0.75-2.01)1.34 (0.93-1.92)
AA1 (0.3)2 (1.6)8.22 (0.44-151.78)1 (0.2)3 (2.3)17.6 (1.76-175.30)14.2 (2.38-84.78)
Ptrend0.0610.0800.010
MIF
    MIFrs738807CC244 (73.9)103 (82.4)1.00392 (73.3)104 (80.6)1.001.00
CT80 (24.2)22 (17.6)0.65 (0.37-1.13)137 (25.6)23 (17.8)0.58 (0.35-0.97)0.61 (0.42-0.89)
TT6 (1.8)0 (0.0)0.006 (1.1)2 (1.6)1.52 (0.29-8.09)0.53 (0.11-2.57)
Ptrend0.0280.0930.007
  • * OR.

  • ORs adjusted for sex, age, study hospital, and distance of residence from hospital.

  • 95% CIs.

  • § ORs adjusted for sex, age, and state of residence.

  • ORs adjusted for study, sex, residence, and age within each study.

  • D' = 1.00 and r2 = 0.06.

  • ** Pairwise 0.74 ≤ D' ≤1.00 and 0.52 ≤ r2 ≤ 0.72.

  • †† D' = 0.99 and r 2 = 0.67.

  • ‡‡ Pairwise D' = 1.00 and 0.42 ≤ r2 ≤0.72.

  • §§ D' = 0.65 and r2 = 0.01. All D' and r2 are reported for pooled controls of European background.