Table 2.

Relationship between hormonal and reproductive factors and ERα or PR expression in ovarian tumors

OR (95%CI)
PheterogeneityOR (95%CI)
Pheterogeneity
ERα+ERα−PR+PR−
Age*
    ≤60 y1.00 (Reference)1.00 (Reference)0.0011.00 (Reference)1.00 (Reference)0.08
    >60 y1.45 (0.76-2.75)0.74 (0.44-1.24)0.95 (0.48-1.87)1.17 (0.74-1.85)
Ptrend0.070.050.340.25
OCs
    Never1.00 (Reference)1.00 (Reference)0.891.00 (Reference)1.00 (Reference)0.81
    Ever0.83 (0.45-1.52)0.83 (0.50-1.35)0.89 (0.46-1.73)0.84 (0.55-1.29)
Ptrend0.230.190.550.16
Parity
    Never1.00 (Reference)1.00 (Reference)0.301.00 (Reference)1.00 (Reference)0.59
    Ever0.37 (0.14-1.03)0.80 (0.27-2.36)0.76 (0.30-1.89)0.30 (0.11-0.82)
    No children1.00 (Reference)1.00 (Reference)1.00 (Reference)1.00 (Reference)
    1-2 children0.49 (0.17-1.42)1.29 (0.43-3.89)0.49 (0.15-1.61)1.11 (0.46-2.65)
    3-4 children0.39 (0.14-1.14)0.87 (0.29-2.62)0.49 (0.16-1.55)0.61 (0.25-1.49)
    5+ children0.90 (0.29-2.79)1.13 (0.33-3.79)0.60 (0.16-2.28)1.04 (0.40-2.71)
Ptrend0.800.220.250.20
Menopausal status at diagnosis§
    Premenopausal1.00 (Reference)1.00 (Reference)0.061.00 (Reference)1.00 (Reference)0.003
    Postmenopausal2.09 (0.74-5.88)0.81 (0.40-1.62)0.41 (0.19-0.91)1.53 (0.74-3.16)
PMH§
    Never1.00 (Reference)1.00 (Reference)0.061.00 (Reference)1.00 (Reference)0.40
    >0-≤5 y1.37 (0.64-2.95)1.25 (0.71-2.17)1.05 (0.48-2.27)1.44 (0.86-2.40)
    >5 y3.05 (1.52-6.12)1.00 (0.51-1.98)0.97 (0.40-2.36)2.57 (1.55-4.27)
Ptrend0.0010.470.190.0003
  • * Adjusted for duration of OC use (months), number of pregnancies (continuous), and menopausal status at diagnosis (premenopausal/postmenopausal).

  • Adjusted for age (continuous), number of pregnancies, and menopausal status at diagnosis.

  • Adjusted for age, duration of OC use, and menopausal status at diagnosis.

  • § Adjusted for age, duration of OC use, and number of pregnancies.

  • Among postmenopausal women.