Table 3.

CYP19 Val80 genotype and ER-negative status in BRCA1/2 carriers

BRCA1/2 statusVal80 genotypeER(−)ER(+)OR (95% CI)PPtrend
<50 y
    BRCA1 carriersA/A641.000.173
G/A2171.95 (0.40-9.44)0.405
G/G1633.53 (0.58-21.51)0.171
Total4314
≥50 y
    BRCA1 carriersA/A751.000.747
G/A14110.75 (0.18-3.21)0.697
G/G750.76 (0.14-4.09)0.746
Total2821
  • NOTE: Adjusted for age.