Table 2.

CYP19 Val80 genotype and breast cancer risk in BRCA1/2 carriers and noncarriers

BRCA1/2 statusVal80 genotypeCases/controlsOR (95% CI)PPtrend
<50 y
    BRCA1 carriersA/A15/24Reference0.028
G/A39/541.41 (0.61-3.26)0.418
G/G27/192.81 (1.09-7.22)0.032
Total81/97
    BRCA2 carriersA/A10/13Reference0.888
G/A22/291.21 (0.42-3.47)0.719
G/G8/150.91 (0.26-3.20)0.885
Total40/57
    NoncarriersA/A28/26Reference0.628
G/A67/511.22 (0.59-2.38)0.549
G/G22/171.20 (0.51-3.21)0.664
Total117/94
≥50 y
    BRCA1 carriersA/A15/12Reference0.321
G/A33/251.05 (0.42-2.63)0.922
G/G13/170.6 (0.21-1.71)0.336
Total61/54
    BRCA2 carriersA/A9/10Reference0.946
G/A20/270.82 (0.28-2.39)0.716
G/G7/80.98 (0.25-3.82)0.978
Total36/45
    NoncarriersA/A153/146Reference0.346
G/A299/3030.94 (0.69-1.24)0.677
G/G166/1371.16 (0.83-1.63)0.366
Total618/586
  • NOTE: Adjusted for age.