Table 4.

HR (95% CI) of liver cancer according to green tea consumption

TotalGreen tea consumption
<3 cups/d
3-4 cups/d
≥5 cups/d
Ptrend
HR (95% CI)HR (95% CI)HR (95% CI)
All subjects
    No. subjects18,8157,0236,1375,655
    Person-years238,51788,48477,97972,054
    No. cases110324434
    Sex, age, and area adjusted1.00 (Reference)1.42 (0.89-2.24)1.13 (0.69-1.85)0.827
    Multivariate adjusted*1.00 (Reference)1.62 (0.97-2.69)1.44 (0.84-2.45)0.108
        Men1.00 (Reference)1.20 (0.64-2.23)1.18 (0.63-2.20)0.287
        Women1.00 (Reference)2.58 (1.01-6.59)1.48 (0.54-4.08)0.397
HCV and/or HBsAg positive
    No. subjects1,499563508428
    Person-years18,0506,7966,1725,082
No. cases92253631
    Sex, age, and area adjusted1.00 (Reference)1.47 (0.87-2.49)1.48 (0.86-2.56)0.250
    Multivariate adjusted*1.00 (Reference)1.68 (0.94-3.02)1.64 (0.91-2.97)0.092
        Men1.00 (Reference)1.41 (0.69-2.88)1.70 (0.85-3.41)0.062
        Women1.00 (Reference)2.41 (0.73-7.92)0.87 (0.24-3.15)0.951
HCV positive
    No. subjects1,058354385319
    Person-years12,4744,1304,6503,694
    No. cases80223226
    Sex, age, and area adjusted1.00 (Reference)1.46 (0.83-2.57)1.42 (0.79-2.58)0.525
    Multivariate adjusted*1.00 (Reference)1.79 (0.95-3.38)1.69 (0.87-3.29)0.154
        Men1.00 (Reference)1.48 (0.67-3.25)1.83 (0.84-3.99)0.110
        Women1.00 (Reference)3.06 (0.82-11.39)1.07 (0.24-4.89)0.874
  • * Model includes sex (stratified; men and women combined only), age (stratified; 5-year age categories), area (stratified; six public health center areas), smoking status (never, past, current), weekly ethanol intake (past, less than weekly, <150 g/wk, ≥150 g/wk), body mass index (<25, 25 to <27, ≥27), history of diabetes mellitus (yes, no), coffee consumption (never, <1, 1-2, ≥3 cups/d), green tea consumption (<3, 3-4, ≥5 cups/d), serum ALT level (IU/L; continuous), HCV infection status (anti-HCV antibody negative, positive; not included in analysis restricted to HCV-positive subjects), and HBV infection status (HbsAg negative, positive).