Analyte | Cases/controls | RR*^{†} | P^{‡} | ||||
---|---|---|---|---|---|---|---|

2nd quartile | 3rd quartile | 4th quartile (high) | |||||

Betaine | 522/959 | 1.16 (0.84-1.61) | 1.31 (0.94-1.81) | 1.36 (0.98-1.88) | 0.08 | ||

Choline | 522/959 | 0.91 (0.65-1.28) | 1.05 (0.74-1.47) | 1.48 (1.07-2.04) | 0.03 | ||

Cysteine | 551/1035 | 0.84 (0.63-1.13) | 0.91 (0.68-1.23) | 0.73 (0.53-1.00) | 0.20 | ||

MMA | 548/1025 | 0.68 (0.50-0.92) | 0.88 (0.66-1.18) | 0.81 (0.60-1.09) | 0.03 | ||

Methionine | 551/1035 | 0.98 (0.73-1.31) | 1.15 (0.85-1.55) | 0.94 (0.69-1.29) | 0.63 | ||

Vitamin B2 | 543/1014 | 1.06 (0.78-1.43) | 1.03 (0.76-1.40) | 1.36 (1.02-1.83) | 0.04 | ||

Vitamin B6 | 543/1014 | 0.99 (0.74-1.33) | 1.07 (0.80-1.43) | 0.91 (0.67-1.23) | 0.94 |

↵* Unadjusted RRs relative the 1st quintile. Adjusting for potential confounders had essentially no effect on the RR estimates (data not shown).

↵† Odds ratios were calculated as estimates of RRs with the use of conditional logistic regression.

↵‡

*P*values were calculated by replacing the categorical quartile variables with the base 2 logarithm of the observed concentration in the logistic regression model.