Table 5.

Prediagnostic antibodies to JC virus and colorectal adenomas by gender, Washington County, MD, 1989-2006

JCV serostatusMales
Females
Cases
Controls
OR* (95% CI)*OR (95% CI)Cases
Controls
OR* (95% CI)*OR (95% CI)
n (%)n (%)n (%)n (%)
JCV-negative20 (32.8)30 (49.2)1.00 (reference)1.00 (reference)45 (72.6)30 (48.4)1.00 (reference)1.00 (reference)
JCV-positive41 (67.2)31 (50.8)2.25 (1.20-4.23)2.31 (1.20-4.46)17 (27.4)32 (51.6)0.32 (0.16-0.63)0.31 (0.14-0.67)
By number of adenomas:
    One adenoma
        JCV-negative11 (39.3)12 (42.9)1.00 (reference)1.00 (reference)27 (75.0)16 (44.4)1.00 (reference)1.00 (reference)
        JCV-positive17 (60.7)16 (57.1)1.17 (0.54-2.53)1.37 (0.48-3.88)9 (25.0)20 (55.6)0.27 (0.11-0.66)0.11 (0.03-0.40)
    Multiple adenomas
        JCV-negative9 (27.3)18 (54.6)1.00 (reference)1.00 (reference)18 (69.2)14 (53.9)1.00 (reference)1.00 (reference)
        JCV-positive24 (72.7)15 (45.5)5.50 (1.51-20.08)6.71 (1.34-33.60)8 (30.8)12 (46.2)0.43 (0.15-1.20)0.40 (0.09-1.90)
By size:
    <0.55cm
        JCV-negative10 (47.6)9 (42.9)1.00 (reference)1.00 (reference)19 (70.4)12 (44.4)1.00 (reference)1.00 (reference)
        JCV-positive11 (52.4)12 (57.1)0.75 (0.26-2.19)0.58 (0.20-1.67)8 (29.6)15 (55.6)0.30 (0.11-0.85)0.30 (0.12-0.74)
    ≥0.55cm
        JCV-negative6 (22.2)15 (55.6)1.00 (reference)1.00 (reference)17 (81.0)14 (66.7)1.00 (reference)1.00 (reference)
        JCV-positive21 (77.8)12 (44.4)4.00 (1.41-11.35)3.83 (1.20-12.25)4 (19.1)7 (33.3)0.50 (0.18-1.41)0.56 (0.20-1.56)
By site:
    Rectum
        JCV-negative3 (20.0)6 (40.0)1.00 (reference)1.00 (reference)9 (81.8)3 (27.3)1.00 (reference)1.00 (reference)
        JCV-positive12 (80.0)9 (60.0)2.50 (0.71-8.83)2.69 (0.87-8.27)2 (18.2)8 (72.7)0.12 (0.00-0.85)NE (NE)
    Distal
        JCV-negative13 (37.1)19 (54.3)1.00 (reference)1.00 (reference)25 (73.5)18 (52.9)1.00 (reference)1.00 (reference)
        JCV-positive22 (62.9)16 (45.7)2.50 (1.03-6.10)2.38 (0.89-6.38)9 (26.5)16 (47.1)0.36 (0.15-0.89)0.31 (0.11-0.87)
    Proximal§
        JCV-negative7 (26.9)13 (50.0)1.00 (reference)1.00 (reference)20 (71.4)16 (57.1)1.00 (reference)1.00 (reference)
        JCV-positive19 (73.1)13 (50.0)4.00 (1.12-14.35)5.31 (0.87-32.27)8 (28.6)12 (42.9)0.50 (0.20-1.22)0.45 (0.15-1.35)
By histology:
    Tubular
        JCV-negative11 (30.6)16 (44.4)1.00 (reference)1.00 (reference)29 (78.4)18 (48.7)1.00 (reference)1.00 (reference)
        JCV-positive25 (69.4)20 (55.6)2.25 (0.92-5.49)1.97 (0.83-4.69)8 (21.6)19 (51.4)0.21 (0.08-0.61)0.19 (0.06-0.56)
    Tubulovillous and villous
        JCV-negative9 (36.0)14 (56.0)1.00 (reference)1.00 (reference)15 (65.2)10 (43.5)1.00 (reference)1.00 (reference)
        JCV-positive16 (64.0)11 (44.0)2.25 (0.92-5.49)2.90 (0.75-11.21)8 (34.8)13 (55.5)0.38 (0.13-1.05)0.33 (0.07-1.65)
  • Abbreviation: NE, not estimable.

  • * Cases and controls matched on age, sex, race, cohort, date of blood draw.

  • Cases and controls matched on age, sex, race, cohort, date of blood draw; conditional logistic regression model included baseline smoking status (current/former/never) and body mass index.

  • Distal includes the descending and sigmoid colon.

  • § Proximal includes the cecum, ascending colon, hepatic flexure, transverse colon, and splenic flexure.