Table 3.

Prediagnostic antibodies to JC virus and colorectal cancer, Washington County, MD, 1975-2006

JCV serostatusMatched analysis*
Multivariable model
Cases
Controls
OR (95% CI)OR (95% CI)
n (%)n (%)
Overall:
    JCV-negative202 (27.7)185 (25.4)1.00 (reference)1.00 (reference)
    JCV-positive527 (72.3)544 (74.6)0.90 (0.79-1.03)0.94 (0.72-1.21)
By sex:
    Males
        JCV-negative84 (26.3)84 (26.3)1.00 (reference)1.00 (reference)
        JCV-positive235 (73.7)235 (73.7)1.00 (0.81-1.24)0.89 (0.59-1.34)
    Females
        JCV-negative118 (28.8)101 (24.6)1.00 (reference)1.00 (reference)
        JCV-positive292 (71.2)309 (75.4)0.84 (0.71-0.99)0.96 (0.68-1.35)
By disease site:
    Colon cancer
        JCV-negative149 (27.8)142 (26.5)1.00 (reference)1.00 (reference)
        JCV-positive387 (72.2)394 (73.5)0.94 (0.81-1.10)1.00 (0.74-1.34)
        Distal colon
        JCV-negative59 (29.2)49 (24.3)1.00 (reference)1.00 (reference)
        JCV-positive143 (70.8)153 (75.7)0.81 (0.64-1.02)0.66 (0.39-1.11)
        Proximal colon§
        JCV-negative76 (25.8)85 (28.8)1.00 (reference)1.00 (reference)
        JCV-positive219 (74.2)210 (71.2)1.15 (0.94-1.41)1.43 (0.96-2.12)
    Rectal cancer
        JCV-negative53 (27.5)43 (22.3)1.00 (reference)1.00 (reference)
        JCV-positive140 (72.5)150 (77.7)0.77 (0.58-1.03)0.69 (0.38-1.27)
By stage at diagnosis:
    Local
        JCV-negative114 (30.2)115 (30.5)1.00 (reference)1.00 (reference)
        JCV-positive263 (69.8)262 (69.5)1.01 (0.88-1.16)1.10 (0.80-1.52)
    Regional
        JCV-negative52 (28.4)40 (21.9)1.00 (reference)1.00 (reference)
        JCV-positive131 (71.6)143 (78.1)0.75 (0.59-0.97)0.66 (0.39-1.13)
    Distant
        JCV-negative25 (22.7)24 (21.8)1.00 (reference)1.00 (reference)
        JCV-positive85 (77.3)86 (78.2)0.96 (0.69-1.33)0.68 (0.23-2.02)
By time between blood draw and diagnosis:
    <1-9 y
        JCV-negative94 (34.4)82 (30.0)1.00(reference)1.00(reference)
        JCV-positive179 (65.6)191 (70.0)0.79 (0.61-1.03)0.77 (0.55-1.08)
    10-19 y
        JCV-negative85 (29.6)89 (31.0)1.00 (reference)1.00 (reference)
        JCV-positive202 (70.4)198 (69.0)1.11 (0.81-1.53)1.32 (0.85-2.06)
    20-31 y
        JCV-negative23 (13.6)15 (8.9)1.00 (reference)
        JCV-positive146 (86.4)154 (91.1)0.60 (0.36-1.01)
  • Abbreviation: JCV, JC virus.

  • * Cases and controls matched on age, sex, race, cohort, and date of blood draw.

  • Results presented for CLUE II participants only; conditional logistic regression model included baseline smoking status and body mass index.

  • Distal includes the descending and sigmoid colon.

  • § Proximal includes the cecum, ascending colon, hepatic flexure, transverse colon, and splenic flexure.

  • 118 case-control pairs who participated in both CLUE cohorts contributed observations to two different strata for the simple models; only their CLUE II observations were included in the multivariable model.