Table 1.

Baseline characteristics of colorectal cancer cases, colorectal adenoma cases, and controls, Washington County, MD, 1975 to 2006

CharacteristicColorectal cancer
Colorectal adenomas
Cases
Controls
PCases
Controls
P
n (%)n (%)n (%)n (%)
Cohort participation*
    CLUE I only (1974)354 (57.9)354 (57.9)0 (0.0)0 (0.0)
    CLUE II only (1989)139 (22.7)139 (22.7)123 (100.0)123 (100.0)
    CLUE I and II118 (19.3)118 (19.3)Matched0 (0.0)0 (0.0)Matched
Age in y (mean ± SD)*56.2 ± 12.456.2 ± 12.3Matched55.1 ± 9.754.9 ± 9.6Matched
Sex*
    Male269 (44.0)269 (44.0)61 (49.6)61 (49.6)
    Female342 (56.0)342 (56.0)Matched62 (50.4)62 (50.4)Matched
Race*
    White600 (98.2)600 (98.2)123 (100.0)123 (100.0)
    Other11 (1.8)11 (1.8)Matched0 (0.0)0 (0.0)Matched
Smoking status
    Current158 (21.7)154 (21.1)21 (17.1)15 (12.2)
    Former230 (31.6)197 (27.0)52 (42.3)41 (33.3)
    Never341 (46.8)378 (51.9)0.1850 (40.7)67 (54.5)0.08
Body mass index (kg/m2)
    <25102 (39.7)104 (40.5)52 (42.3)51 (41.5)
    25-30103 (40.1)110 (42.8)49 (39.8)54 (43.9)
    >3052 (20.2)43 (16.7)0.5122 (17.9)18 (14.6)0.71
NSAID use at baseline
    Yes176 (24.1)209 (28.7)38 (30.9)29 (23.6)
    No553 (75.9)520 (71.3)0.0585 (69.1)94 (76.4)0.18
Family history of colorectal cancer
    No124 (78.0)150 (86.7)86 (71.7)98 (83.8)
    Yes35 (22.0)23 (13.3)0.0434 (28.3)19 (16.2)0.03
Recent hormone use§
    None178 (87.7)185 (89.4)49 (81.7)42 (67.7)
    Any25 (12.3)22 (10.6)0.6411 (18.3)20 (32.3)0.10
  • Abbreviation: NSAID, nonsteroidal anti-inflammatory drugs.

  • * Matching factors.

  • Data obtained from CLUE II participants only.

  • NSAID use within 48 h prior to blood draw.

  • § Data presented for females only.